Searching across hundreds of databases
In the dorsal root ganglia (DRG), two types of glial cells (Schwann cells and satellite glial cells) have been identified based on cell morphology and expression of specific markers. In the present study, we observed unknown glial cells that were positive for p75 neurotrophin receptor (p75NTR), and therefore were immunohistochemically and ultrastructurally characterized for the first time. These cells exhibited stronger immunoreactivity against an anti-p75NTR antibody than the DRG neurons (hereafter referred to as p75NTR++ cells). Moreover, these cells covered the glial cells surrounding proximal process of the large-diameter DRG neurons. The proximal process is called "dendro-axon." The p75NTR++ cells were predominantly distributed where the first myelinating Schwann cells appear. The p75NTR++ cells were also positive for the pan-glial cell markers S100, nestin, and Sox10, but negative for fibroblast and macrophage markers. Moreover, they were negative for a satellite glial cell marker, inwardly rectifying potassium channel Kir4.1, as well as a nonmyelinating Schwann cell marker, glial fibrillary acidic protein. In addition, their morphological features were distinct from those of the myelinating Schwann cells. To investigate the three-dimensional ultrastructure of the p75NTR++ cells, we used array tomography combined with correlative light and electron microscopic observation. Three-dimensional ultrastructural observation revealed that the p75NTR++ cells loosely covered glial cells around the dendro-axons with highly ramified processes. Glial cells with these morphological features have not been reported before, indicating that the p75NTR++ glial cells are a new glial cell type in the DRG. Our results will give new insights into cell-cell relationships.
Pubmed ID: 30779139 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This polyclonal targets p75 NGF Receptor
View all literature mentionsThis polyclonal targets NGFR
View all literature mentionsThis monoclonal targets Nestin
View all literature mentionsThis polyclonal targets Iba1
View all literature mentionsThis monoclonal targets S100 Protein
View all literature mentionsThis monoclonal targets GFAP (2E1)
View all literature mentionsThis monoclonal targets Bromodeoxyuridine (BrdU)
View all literature mentionsThis unknown targets Kir4.1 (KCNJ10) Channel
View all literature mentionsThis unknown targets Prokaryotic recombinant fusion protein corresponding to a 1086bp Ki67 motif-containing cDNA fragment
View all literature mentionsThis monoclonal targets Neurofilament 200 (Phos. and Non-Phos.) antibody produced in mouse
View all literature mentionsThis polyclonal targets SOX2
View all literature mentionsThis polyclonal targets Myelin Protein Zero
View all literature mentionsThis unknown targets Raised against peptide mapping to N-terminus of sox-10 of human origin
View all literature mentionsThis monoclonal targets Rat Neurotrophin Receptor p75NTR
View all literature mentionsThis monoclonal targets TrkA antibody [EP1058Y]
View all literature mentionsThis polyclonal targets S100 isolated from cow brain.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsThis polyclonal targets p75 NGF Receptor
View all literature mentionsThis polyclonal targets NGFR
View all literature mentionsThis monoclonal targets Bromodeoxyuridine (BrdU)
View all literature mentionsThis unknown targets Prokaryotic recombinant fusion protein corresponding to a 1086bp Ki67 motif-containing cDNA fragment
View all literature mentionsThis monoclonal targets TrkA antibody [EP1058Y]
View all literature mentionsThis polyclonal targets Iba1
View all literature mentionsThis monoclonal targets GFAP (2E1)
View all literature mentionsThis polyclonal targets Myelin Protein Zero
View all literature mentionsThis unknown targets Kir4.1 (KCNJ10) Channel
View all literature mentionsThis unknown targets Raised against peptide mapping to N-terminus of sox-10 of human origin
View all literature mentionsThis polyclonal targets SOX2
View all literature mentionsThis monoclonal targets Nestin
View all literature mentionsThis polyclonal targets p75 NGF Receptor
View all literature mentionsThis monoclonal targets S100 Protein
View all literature mentionsThis polyclonal targets S100 isolated from cow brain.
View all literature mentionsThis monoclonal targets Neurofilament 200 (Phos. and Non-Phos.) antibody produced in mouse
View all literature mentionsThis monoclonal targets Rat Neurotrophin Receptor p75NTR
View all literature mentionsThis polyclonal targets NGFR
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsThis monoclonal targets Bromodeoxyuridine (BrdU)
View all literature mentionsThis unknown targets Prokaryotic recombinant fusion protein corresponding to a 1086bp Ki67 motif-containing cDNA fragment
View all literature mentionsThis monoclonal targets TrkA antibody [EP1058Y]
View all literature mentionsThis polyclonal targets Iba1
View all literature mentionsThis polyclonal targets S100 isolated from cow brain.
View all literature mentionsThis monoclonal targets Neurofilament 200 (Phos. and Non-Phos.) antibody produced in mouse
View all literature mentionsThis monoclonal targets Rat Neurotrophin Receptor p75NTR
View all literature mentionsThis polyclonal targets NGFR
View all literature mentionsThis polyclonal targets p75 NGF Receptor
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsThis monoclonal targets GFAP (2E1)
View all literature mentionsThis polyclonal targets Myelin Protein Zero
View all literature mentionsThis unknown targets Kir4.1 (KCNJ10) Channel
View all literature mentionsThis unknown targets Raised against peptide mapping to N-terminus of sox-10 of human origin
View all literature mentionsThis polyclonal targets SOX2
View all literature mentionsThis monoclonal targets Nestin
View all literature mentionsThis monoclonal targets S100 Protein
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
