Alzheimer's disease (AD) is the most common form of dementia. Mutations in the gene PSEN1 encoding Presenilin1 are known to cause familial forms of AD with early age of onset. The most common mutation in the PSEN1 gene is the E280A mutation. iPSCs are an optimal choice for modeling AD, as they can be differentiated in vitro into neural cells. Here, we report the generation of two isogenic iPSC lines with either a homozygous or a heterozygous E280A mutation in the PSEN1 gene. The mutation was introduced into an iPSC line from a healthy individual using the CRISPR-Cas9 technology. Resource table.
Pubmed ID: 30769329 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Commercial instrument and chemical vendor. Developer and manufacturer of specialized technological products for life science research and clinical diagnostics markets.
View all literature mentionsCommercial vendor and service provider of laboratory reagents and antibodies. Supplier of scientific instrumentation, reagents and consumables, and software services.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsThis polyclonal targets Pax-6
View all literature mentionsThis unknown targets Human TRA-1-81 Antigen
View all literature mentionsThis monoclonal targets Smooth Muscle Actin
View all literature mentionsThis monoclonal targets TRA-1-60-R
View all literature mentionsThis polyclonal targets Human Nanog
View all literature mentionsThis monoclonal targets SSEA-4
View all literature mentionsThis polyclonal targets POU5F1
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets Nestin clone 10C2
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets SSEA-3
View all literature mentionsThis monoclonal targets Human SSEA-4
View all literature mentionsThis polyclonal targets Alpha-1-fetoprotein
View all literature mentionsThis monoclonal targets TRA-1-81
View all literature mentions