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Publication

PI3K inhibitors protect against glucocorticoid-induced skin atrophy.

Shivani Agarwal | Salida Mirzoeva | Ben Readhead | Joel T Dudley | Irina Budunova

EBioMedicine | 2019

Skin atrophy is a major adverse effect of topical glucocorticoids. We recently reported that REDD1 (regulated in development and DNA damage 1) and FKBP51 (FK506 binding protein 5), negative regulators of mTOR/Akt signaling, are induced by glucocorticoids in mouse and human skin and are central drivers of steroid skin atrophy. Thus, we hypothesized that REDD1/FKBP51 inhibitors could protect skin against catabolic effects of glucocorticoids.

Pubmed ID: 30737086 RIS Download

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Associated grants

Agency: NIAMS NIH HHS, United States
Id: P30 AR057216
Agency: NIAID NIH HHS, United States
Id: R01 AI125366
Agency: NIGMS NIH HHS, United States
Id: R01 GM112945

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