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Slit-Robo signaling has been characterized as a repulsive signal for precise axon pathfinding and cell migration during embryonic development. Here, we describe a role for Sox2 in the regulation of Robo1 in Schwann cells and for Slit3-Robo1 signaling in controlling axon guidance within the newly formed nerve bridge following peripheral nerve transection injury. In particular, we show that macrophages form the outermost layer of the nerve bridge and secrete high levels of Slit3, while migratory Schwann cells and fibroblasts inside the nerve bridge express the Robo1 receptor. In line with this pattern of Slit3 and Robo1 expression, we observed multiple axon regeneration and cell migration defects in the nerve bridge of Sox2-, Slit3-, and Robo1-mutant mice. Our findings have revealed important functions for macrophages in the peripheral nervous system, utilizing Slit3-Robo1 signaling to control correct peripheral nerve bridge formation and precise axon targeting to the distal nerve stump following injury.
Pubmed ID: 30726731 RIS Download
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View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis polyclonal targets Mouse MMR
View all literature mentionsThis polyclonal targets SLIT3 (N-terminal) antibody produced in rabbit
View all literature mentionsThis polyclonal targets MBP (D-18)
View all literature mentionsThis polyclonal targets Robo1 antibody
View all literature mentionsThis monoclonal targets F4/80 antibody [CI:A3-1]
View all literature mentionsThis polyclonal targets S100 isolated from cow brain.
View all literature mentionsThis polyclonal targets Iba1
View all literature mentionsThis polyclonal targets Fibronectin
View all literature mentionsThis monoclonal targets Glyceraldehyde-3-PDH (GAPDH)
View all literature mentionsThis polyclonal targets Rat Vimentin
View all literature mentionsThis polyclonal targets robo2 (H-100)
View all literature mentionsThis polyclonal targets Human/Mouse Slit3 Affinity Purified Ab
View all literature mentionsThis polyclonal targets 200 kD Neurofilament Heavy - Neuronal Marker
View all literature mentionsThis monoclonal targets Mouse CD68
View all literature mentionsThis polyclonal targets Krox-20
View all literature mentionsThis polyclonal targets p44/42 MAPK (Erk1/2)
View all literature mentionsThis polyclonal targets Ki67 antibody - Proliferation Marker
View all literature mentionsThis monoclonal targets TUBB2A
View all literature mentionsThis polyclonal targets Myelin Protein Zero antibody produced in goat
View all literature mentionsThis monoclonal targets Jun
View all literature mentionsThis polyclonal targets SOX2
View all literature mentionsThis polyclonal targets Robo1 antibody
View all literature mentionsThis polyclonal targets S100 isolated from cow brain.
View all literature mentionsThis polyclonal targets Mouse MMR
View all literature mentionsThis polyclonal targets SLIT3 (N-terminal) antibody produced in rabbit
View all literature mentionsThis monoclonal targets F4/80 antibody [CI:A3-1]
View all literature mentionsThis polyclonal targets MBP (D-18)
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