The adult mammalian retina is typically incapable of regeneration when damaged by disease or trauma. Restoration of function would require generation of new adult neurons, something that until recently, mammals were thought to be incapable of doing. However, previous studies from this laboratory have shown that the α7 nicotinic acetylcholine receptor (α7 nAChR) agonist, PNU-282987, induces cell cycle reentry of Müller glia and generation of mature retinal neurons in adult rats, in the absence of detectible injury. This study analyzes how PNU-282987 treatment in RPE leads to robust BrdU incorporation in Müller glia in adult mice and leads to generation of Müller-derived retinal progenitors and neuronal differentiation.
Pubmed ID: 30721274 RIS Download
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View all literature mentionsA commercial antibody supplier which supplies primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits.
View all literature mentionslaboratory mouse with name 129/SvJ from MGI.
View all literature mentionsThis polyclonal targets Cone Arrestin
View all literature mentionsThis monoclonal targets Pax6
View all literature mentionsThis polyclonal targets RFP
View all literature mentionsThis polyclonal targets BrdU - Proliferation Marker
View all literature mentionsThis polyclonal targets Cone Arrestin
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