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Immune responses counteract infections but also cause collateral damage to hosts. Oligoadenylate synthetase 1 (OAS1) binds double-stranded RNA from invading viruses and produces 2'-5' linked oligoadenylate (2-5A) to activate ribonuclease L (RNase L), which cleaves RNA to inhibit virus replication. OAS1 can also undergo autoactivation by host RNAs, a potential trade-off to antiviral activity. We investigated functional variation in primate OAS1 as a model for how immune pathways evolve to mitigate costs and observed a surprising frequency of loss-of-function variation. In gorillas, we identified a polymorphism that severely decreases catalytic function, mirroring a common variant in humans that impairs 2-5A synthesis through alternative splicing. OAS1 loss-of-function variation is also common in monkeys, including complete loss of 2-5A synthesis in tamarins. The frequency of loss-of-function alleles suggests that costs associated with OAS1 activation can be so detrimental to host fitness that pathogen-protective effects are repeatedly forfeited.
Pubmed ID: 30713099 RIS Download
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Software for automatic general image analysis. It provides fully automatic analysis of 1-D gels including lane creation, background subtraction, band detection, molecular weight calibration, quantity calibration, and normalization. Editing tools are provided for cropping, rotating, and filtering images.
View all literature mentionsThis monoclonal targets Actin
View all literature mentionsThis monoclonal targets Human RNASEL
View all literature mentionsThis unknown targets
View all literature mentionsThis unknown targets Human OAS1
View all literature mentionsCell line N2.261 is a Hybridoma with a species of origin Mus musculus
View all literature mentionsCell line AG05313 is a Finite cell line with a species of origin Leontocebus fuscicollis (Brown-mantled tamarin)
View all literature mentionsCell line PR00742 is a Finite cell line with a species of origin Plecturocebus moloch
View all literature mentionsCell line PR01193 is a Finite cell line with a species of origin Chlorocebus aethiops
View all literature mentionsCell line PR00240 is a Finite cell line with a species of origin Colobus guereza kikuyuensis (Mt. Kenya guereza)
View all literature mentionsCell line PR00036 is a Finite cell line with a species of origin Papio anubis (Olive baboon)
View all literature mentionsCell line PR00716 is a Finite cell line with a species of origin Miopithecus talapoin
View all literature mentionsCell line PR00239 is a Finite cell line with a species of origin Pithecia pithecia (White-faced saki)
View all literature mentionsCell line AG05252 is a Finite cell line with a species of origin Pongo pygmaeus (Bornean orangutan)
View all literature mentionsCell line AG21765 is a Finite cell line with a species of origin Gorilla gorilla gorilla (Western lowland gorilla)
View all literature mentionsCell line PR00226 is a Finite cell line with a species of origin Pan troglodytes
View all literature mentionsCell line AG06252 is a Finite cell line with a species of origin Macaca mulatta (Rhesus macaque)
View all literature mentionsCell line AG05252 is a Finite cell line with a species of origin Pongo pygmaeus (Bornean orangutan)
View all literature mentionsCell line N2.261 is a Hybridoma with a species of origin Mus musculus
View all literature mentionsCell line PR00226 is a Finite cell line with a species of origin Pan troglodytes
View all literature mentionsThis monoclonal targets Actin
View all literature mentionsThis unknown targets Human OAS1
View all literature mentionsThis monoclonal targets Human RNASEL
View all literature mentionsCell line AG21765 is a Finite cell line with a species of origin Gorilla gorilla gorilla (Western lowland gorilla)
View all literature mentionsThis unknown targets
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