Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Publication

Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis.

Immunity | 2019

The tolerogenic microenvironment of the liver is associated with impaired hepatic T cell function. Here, we examined the contribution of liver-resident natural killer (LrNK) cells, a prominent hepatic NK cell compartment, to T cell antiviral responses in the liver. The number of virus-specific T cells increased in LrNK-cell-deficient mice during both acute and chronic lymphocytic choriomeningitis virus infection. Upon infection with adenovirus, hepatic T cells from these mice produced more cytokines, which was accompanied by reduced viral loads. Transfer of LrNK cells into LrNK-cell-deficient or wild-type mice inhibited hepatic T cell function, resulting in impaired viral clearance, whereas transfer of conventional NK cells promoted T cell antiviral responses. LrNK-cell-mediated inhibition of T cell function was dependent on the PD-1-PD-L1 axis. Our findings reveal a role for LrNK cells in the regulation of T cell immunity and provide insight into the mechanisms of immune tolerance in the liver.

Pubmed ID: 30709740 RIS Download

Research resources used in this publication

Additional research tools detected in this publication

None found

Antibodies used in this publication

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

PerCP/Cyanine5.5 anti-mouse CD19 (antibody)

RRID:AB_2072925

This monoclonal targets CD19

View all literature mentions

LEAF™ Purified anti-mouse CD274 (B7-H1, PD-L1) (antibody)

RRID:AB_961232

This monoclonal targets CD274 (B7-H1, PD-L1)

View all literature mentions

Syrian Hamster Anti-CD28 Monoclonal Antibody, Unconjugated, Clone 37.51 (antibody)

RRID:AB_394763

This monoclonal targets CD28

View all literature mentions

Anti-Mouse Trail Monoclonal Antibody, Unconjugated, Clone N2B2 (antibody)

RRID:AB_469163

This monoclonal targets Mouse Trail

View all literature mentions

Purified NA/LE Hamster Anti-Mouse CD3e Clone 145-2C11 (antibody)

RRID:AB_394590

This monoclonal targets CD3e

View all literature mentions

APC anti-mouse CD279 (PD-1) (antibody)

RRID:AB_2159183

This monoclonal targets CD279

View all literature mentions

PE anti-mouse TNF-alpha (antibody)

RRID:AB_315427

This monoclonal targets TNF-alpha

View all literature mentions

PerCP/Cyanine5.5 anti-mouse CD335 (NKp46) (antibody)

RRID:AB_10641137

This monoclonal targets CD335

View all literature mentions

PE anti-T-bet (antibody)

RRID:AB_2200542

This monoclonal targets T-bet

View all literature mentions

Brilliant Violet 605(TM) anti-mouse NK-1.1 (antibody)

RRID:AB_2562274

This monoclonal targets NK-1.1

View all literature mentions

Brilliant Violet 421(TM) anti-mouse TNF-alpha (antibody)

RRID:AB_2562902

This monoclonal targets TNF-alpha

View all literature mentions

PE/Cyanine7 anti-mouse NK-1.1 (antibody)

RRID:AB_389364

This monoclonal targets NK-1.1

View all literature mentions

PE anti-mouse CD275 (B7-RP1, ICOSL, B7H2) (antibody)

RRID:AB_2248797

This monoclonal targets CD275

View all literature mentions

PerCP/Cyanine5.5 anti-mouse IL-2 (antibody)

RRID:AB_2123676

This monoclonal targets IL-2

View all literature mentions

PE anti-mouse CD200R (OX2R) (antibody)

RRID:AB_2074080

This monoclonal targets CD200R

View all literature mentions

PE anti-mouse IFN-gamma (antibody)

RRID:AB_315402

This monoclonal targets IFN-gamma

View all literature mentions

APC/Cyanine7 anti-mouse NK-1.1 (antibody)

RRID:AB_830871

This monoclonal targets NK-1.1

View all literature mentions

APC/Cyanine7 anti-mouse CD45.2 (antibody)

RRID:AB_830789

This monoclonal targets CD45.2

View all literature mentions

PE/Cyanine7 anti-mouse CD45.1 (antibody)

RRID:AB_1134168

This monoclonal targets CD45.1

View all literature mentions

APC anti-mouse/rat/human CD27 (antibody)

RRID:AB_2073425

This monoclonal targets CD27

View all literature mentions

PE/Cyanine7 anti-mouse CD45 (antibody)

RRID:AB_312979

This monoclonal targets CD45

View all literature mentions

FITC anti-mouse CD200R (OX2R) (antibody)

RRID:AB_2244385

This monoclonal targets CD200R

View all literature mentions

APC/Cyanine7 anti-mouse CD3epsilon (antibody)

RRID:AB_1877170

This monoclonal targets CD3epsilon

View all literature mentions

PerCP/Cyanine5.5 anti-mouse CD8a (antibody)

RRID:AB_2075238

This monoclonal targets CD8a

View all literature mentions

PE/Cyanine7 anti-mouse CD3epsilon (antibody)

RRID:AB_312685

This monoclonal targets CD3epsilon

View all literature mentions

FITC anti-mouse CD4 (antibody)

RRID:AB_312713

This monoclonal targets CD4

View all literature mentions

Perforin Monoclonal Antibody (eBioOMAK-D), APC, eBioscience (antibody)

RRID:AB_469514

This monoclonal targets Perforin

View all literature mentions

APC/Cyanine7 anti-mouse/human CD11b (antibody)

RRID:AB_830642

This monoclonal targets CD11b

View all literature mentions

Anti-Mouse Granzyme B PE 25 ug (antibody)

RRID:AB_466216

This monoclonal targets Mouse Granzyme B PE 25 ug

View all literature mentions

CD39 Monoclonal Antibody (24DMS1), PE, eBioscience (antibody)

RRID:AB_1210740

This monoclonal targets CD39

View all literature mentions

Anti-Mouse DR5 (Trail-R2, TrailR2) Monoclonal Antibody, Phycoerythrin (PE) Conjugated, Clone MD5-1 (antibody)

RRID:AB_466000

This monoclonal targets Mouse DR5 (Trail-R2, TrailR2)

View all literature mentions

IFN-γ (antibody)

RRID:AB_2738419

This monoclonal targets IFN-γ

View all literature mentions

CD73 Monoclonal Antibody (eBioTY/11.8 (TY/11.8)), PE, eBioscience (antibody)

RRID:AB_763513

This monoclonal targets CD73

View all literature mentions

Anti-Mouse Trail Monoclonal Antibody, Phycoerythrin (PE) Conjugated, Clone N2B2 (antibody)

RRID:AB_466058

This monoclonal targets Mouse Trail

View all literature mentions

Rat Anti-CD274 Monoclonal Antibody, Phycoerythrin Conjugated, Clone MIH5 (antibody)

RRID:AB_397018

This monoclonal targets CD274

View all literature mentions

CD49b (Integrin α2 chain) (antibody)

RRID:AB_2737983

This monoclonal targets CD49b (Integrin α2 chain)

View all literature mentions

CD223 (antibody)

RRID:AB_394374

This monoclonal targets CD223

View all literature mentions

CD49b/Pan-NK Cells (antibody)

RRID:AB_395094

This monoclonal targets CD49b/Pan-NK Cells

View all literature mentions

Rat Anti-CD107a Monoclonal Antibody, FITC Conjugated, Clone 1D4B (antibody)

RRID:AB_395057

This monoclonal targets CD107a (LAMP-1)

View all literature mentions

CD49a (Integrin α1 chain) (antibody)

RRID:AB_2740560

This monoclonal targets CD49a (Integrin α1 chain)

View all literature mentions

CD273 (antibody)

RRID:AB_1645223

This monoclonal targets CD273

View all literature mentions

BV510 Rat Anti-Mouse CD8a Antibody (antibody)

RRID:AB_2687548

This monoclonal targets Mouse CD8a

View all literature mentions

PerCP-Cy™5.5 Hamster Anti-Rat/Mouse CD49a (antibody)

RRID:AB_2734135

This monoclonal targets CD49a

View all literature mentions

BV510 Rat Anti-Mouse CD4 Antibody (antibody)

RRID:AB_2687550

This monoclonal targets Mouse CD4

View all literature mentions

CD49a (antibody)

RRID:AB_11153117

This monoclonal targets CD49a

View all literature mentions

CD49a (antibody)

RRID:AB_11153312

This monoclonal targets CD49a

View all literature mentions

PerCP/Cyanine5.5 anti-mouse CD19 (antibody)

RRID:AB_2072925

This monoclonal targets CD19

View all literature mentions

About

The SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.

Recent News Entries

New Release: NeuroMorpho.Org Version 8.6 (12/4/23), with 14,452 new tracings from 45 datasets

Dr. Martone on BrainFacts.org a FAIR video

With 2023 there are new NIH guidelines on data deposition, are you ready?

Contact Us

FAIR Data Informatics Lab

University of California, San Diego
9500 Gilman Drive, Mail Code 0608
La Jolla, CA 92093-0608
United States

info  scicrunch.org

About SciCrunch | Privacy Policy | Terms of Service

SciCrunch