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Opposite effects of cannabinoid CB1 and CB2 receptors on antipsychotic clozapine-induced cardiotoxicity.

British journal of pharmacology | 2019

Clozapine is an atypical antipsychotic drug that is very efficacious in treating psychosis, but the risk of severe cardiotoxicity limits its clinical use. The present study investigated the harmful effects of clozapine on myocardium and assessed the involvement of cannabinoid receptors in its cardiotoxicity.

Pubmed ID: 30707759 RIS Download

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Cannabinoid receptor 2 antibody (antibody)

RRID:AB_374359

This polyclonal targets Cannabinoid Receptor II

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CB1 Receptor (D5N5C) (antibody)

RRID:AB_2756361

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ImageJ (software resource)

RRID:SCR_003070

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BALB/cByJSlacc (organism)

RRID:MGI:6272006

laboratory mouse with name BALB/cByJSlacc from MGI.

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HL-1 (cell line)

RRID:CVCL_0303

Cell line HL-1 is a Transformed cell line with a species of origin Mus musculus (Mouse)

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SPSS (software resource)

RRID:SCR_002865

Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.

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ImageJ (software resource)

RRID:SCR_003070

Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.

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