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Publication

Mafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function.

Cell reports | 2019

Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV+) and somatostatin (SST+) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST+ cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.

Pubmed ID: 30699346 RIS Download

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Associated grants

Agency: NINDS NIH HHS, United States
Id: R01 NS096369
Agency: NINDS NIH HHS, United States
Id: R00 NS078118
Agency: NIMH NIH HHS, United States
Id: R01 MH081880
Agency: NIDCD NIH HHS, United States
Id: R01 DC009223
Agency: NIMH NIH HHS, United States
Id: R37 MH049428
Agency: NIMH NIH HHS, United States
Id: R01 MH049428

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RRID:SCR_002798

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RRID:SCR_003086

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RRID:SCR_005375

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RRID:SCR_001224

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