Chronic inflammation drives the progression of colorectal cancer (CRC). Increased expression of interleukin (IL)-17A is associated with poor prognosis, and IL-17A blockade curbs tumor progression in preclinical models of CRC. Here we examined the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment. Genetic deletion of the IL-1 receptor (IL-1R1) in epithelial cells alleviated tumorigenesis in the APC model of CRC, demonstrating a cell-autonomous role for IL-1 signaling in early tumor seed outgrowth. T cell specific ablation of IL-1R1 decreased tumor-elicited inflammation dependent on IL-17 and IL-22, thereby reducing CRC progression. The pro-tumorigenic roles of IL-1 were counteracted by its effects on myeloid cells, particularly neutrophils, where IL-1R1 ablation resulted in bacterial invasion into tumors, heightened inflammation and aggressive CRC progression. Thus, IL-1 signaling elicits cell-type-specific responses, which, in aggregate, set the inflammatory tone of the tumor microenvironment and determine the propensity for disease progression.
Pubmed ID: 30650375 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsAn algorithm for detecting chimeric sequences.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 23,2023.Software package for comparison and analysis of microbial communities, primarily based on high-throughput amplicon sequencing data, but also supporting analysis of other types of data. QIMME analyzes and transforms raw sequencing data generated on Illumina or other platforms to publication quality graphics and statistics.
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets IL-22
View all literature mentionsThis monoclonal targets TCR beta
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets IL-17A
View all literature mentionsThis monoclonal targets TCR gamma/delta
View all literature mentionsThis monoclonal targets IL-17A
View all literature mentionsThis monoclonal targets TCR gamma/delta
View all literature mentionsThis monoclonal targets TCR gamma/delta
View all literature mentionsThis monoclonal targets TCR beta
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets TCR beta
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD90.2 (Thy-1.2)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets Mouse Myeloperoxidase
View all literature mentionsThis polyclonal targets Phospho-Stat3 (Tyr705) Antibody detects endogenous levels of Stat3 only when phosphorylated at Tyr705. The antibody does not cross-react with other Stat proteins when phosphorylated on the corresponding tyrosine residue. Does cross-react withPhospho-EGFR
View all literature mentionsThis monoclonal targets Non-phospho (Active) β-Catenin (Ser45) (D2U8Y) XP® Rabbit mAb recognizes endogenous levels of β-catenin protein only when Ser45 is not phosphorylated.
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets Histone H3
View all literature mentionsThis polyclonal targets Histone H3 (citrulline 2 + 8 + 17) antibody - ChIP Grade
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD8b
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets Ki67 - Proliferation Marker
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets IL-22
View all literature mentionsThis monoclonal targets TCR beta
View all literature mentions