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Adenosine deaminase associated with RNA1 (ADAR1) deregulation contributes to therapeutic resistance in many malignancies. Here we show that ADAR1-induced hyper-editing in normal human hematopoietic progenitors impairs miR-26a maturation, which represses CDKN1A expression indirectly via EZH2, thereby accelerating cell-cycle transit. However, in blast crisis chronic myeloid leukemia progenitors, loss of EZH2 expression and increased CDKN1A oppose cell-cycle transit. Moreover, A-to-I editing of both the MDM2 regulatory microRNA and its binding site within the 3' UTR region stabilizes MDM2 transcripts, thereby enhancing blast crisis progenitor propagation. These data reveal a dual mechanism governing malignant transformation of progenitors that is predicated on hyper-editing of cell-cycle-regulatory miRNAs and the 3' UTR binding site of tumor suppressor miRNAs.
Pubmed ID: 30612940 RIS Download
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Commercial organization which provides reagents and services for molecular biology research. Its services include clone collections, microRNA solutions, genome editing, qPCR products, and fluorescent labeling and detection.
View all literature mentionsSoftware for aligning sequencing reads against large reference genome. Consists of three algorithms: BWA-backtrack, BWA-SW and BWA-MEM. First for sequence reads up to 100bp, and other two for longer sequences ranged from 70bp to 1Mbp.
View all literature mentionsSoftware performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
View all literature mentionsPython based tools to process, visualize and analyse high-throughput sequencing data, such as ChIP-seq, RNA-seq or MNase-seq. Implemented within Galaxy framework. Used to perform complete bioinformatic workflows ranging from quality controls and normalizations of aligned reads to integrative analyses, including clustering and visualization approaches.
View all literature mentionsSoftware performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
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View all literature mentionsThis monoclonal targets p21
View all literature mentionsThis monoclonal targets CD19
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View all literature mentionsCell line K-562 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis polyclonal targets RCJMB04_4h19
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis monoclonal targets CD123 (IL-3 Receptor α)
View all literature mentionsThis monoclonal targets ADAR1 antibody [EPR7033]
View all literature mentionsCell line K-562 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD2
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD56 (NCAM-1)
View all literature mentionsThis monoclonal targets CD45RA
View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis polyclonal secondary targets Rabbit IgG (H+L)
View all literature mentionsThis monoclonal targets p21
View all literature mentionsThis polyclonal secondary targets IgG
View all literature mentionsThis polyclonal targets p21 antibody
View all literature mentionsThis unknown targets Biotin
View all literature mentionsThis monoclonal targets CD34
View all literature mentionsThis monoclonal targets Human CD38
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis polyclonal targets H3K27me3
View all literature mentionsThis polyclonal targets
View all literature mentionsThis unknown targets H3K27me3
View all literature mentionsThis polyclonal targets RCJMB04_4h19
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