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Alzheimer's disease (AD) is the most common form of dementia, impairing cognitive and motor functions. One of the pathological hallmarks of AD is neuronal loss, which is not reflected in mouse models of AD. Therefore, the role of neuronal death is still uncertain. Here, we used a Drosophila AD model expressing a secreted form of human amyloid-β42 peptide and showed that it recapitulates key aspects of AD pathology, including neuronal death and impaired long-term memory. We found that neuronal apoptosis is mediated by cell fitness-driven neuronal culling, which selectively eliminates impaired neurons from brain circuits. We demonstrated that removal of less fit neurons delays β-amyloid-induced brain damage and protects against cognitive and motor decline, suggesting that contrary to common knowledge, neuronal death may have a beneficial effect in AD.
Pubmed ID: 30590040 RIS Download
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Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsOpen source software written in R that tracks a single animal walking in a homogenous environment (Buritrack) and analyzes its trajectory. It extracts eleven metrics and includes correlation analyses and a Principal Components Analysis (PCA). It was designed to be easily customized to personal requirements. In combination with inexpensive hardware, these tools can readily be used for teaching and research purposes. Buritrack is a program to track individual Drosophila fruit flies online with any camera as they walk in Buridan's paradigm. The program extracts the coordinate locations of the fly and stores them in a text file.
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets Mouse Drosophila fasciclin II
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis monoclonal targets Abeta 42
View all literature mentionsThis unknown targets Cleaved Dcp-1 (Asp216)
View all literature mentionsThis monoclonal targets elav Drosophila protein; embryonic lethal abnormal vision
View all literature mentionsThis polyclonal targets Myc-Tag
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-DIAP1.H}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Hsap\SNCA.F}5B from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=GAL4-ninaE.GMR}12 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; PBac{y[+mDint2] w[+mC]=UAS-Abeta.1-40}VK00033/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-lacZ.NZ}20b from BDSC.
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis unknown targets Cleaved Dcp-1 (Asp216)
View all literature mentionsThis monoclonal targets Abeta 42
View all literature mentionsThis polyclonal targets Myc-Tag
View all literature mentionsThis monoclonal targets elav Drosophila protein; embryonic lethal abnormal vision
View all literature mentionsThis monoclonal targets Mouse Drosophila fasciclin II
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Hsap\SNCA.F}5B from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; PBac{y[+mDint2] w[+mC]=UAS-Abeta.1-40}VK00033/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-lacZ.NZ}20b from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-DIAP1.H}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=GAL4-ninaE.GMR}12 from BDSC.
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