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A hallmark of adult hematopoiesis is the continuous replacement of blood cells with limited lifespans. While active hematopoietic stem cell (HSC) contribution to multilineage hematopoiesis is the foundation of clinical HSC transplantation, recent reports have questioned the physiological contribution of HSCs to normal/steady-state adult hematopoiesis. Here, we use inducible lineage tracing from genetically marked adult HSCs and reveal robust HSC-derived multilineage hematopoiesis. This commences via defined progenitor cells, but varies substantially in between different hematopoietic lineages. By contrast, adult HSC contribution to hematopoietic cells with proposed fetal origins is neglible. Finally, we establish that the HSC contribution to multilineage hematopoiesis declines with increasing age. Therefore, while HSCs are active contributors to native adult hematopoiesis, it appears that the numerical increase of HSCs is a physiologically relevant compensatory mechanism to account for their reduced differentiation capacity with age.
Pubmed ID: 30561324 RIS Download
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Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsAmerican chemical, life science and biotechnology company owned by Merck KGaA. Merger of Sigma Chemical Company and Aldrich Chemical Company. Provides organic and inorganic chemicals, building blocks, reagents, advanced materials and stable isotopes for chemical synthesis, medicinal chemistry and materials science, antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, proteins, peptides, amino acids and their derivatives.
View all literature mentionsAn Antibody supplier and subset of ThermoFisher Scientific which provides fluorescence reagents for various experiments and methods.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD16/CD32
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets Ly-6A/E
View all literature mentionsThis monoclonal targets CD48
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD41a
View all literature mentionsThis monoclonal targets CD48
View all literature mentionsThis monoclonal targets TER-119
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets TER-119
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD115
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD127
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets TER-119
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets TCR gamma/delta
View all literature mentionsThis monoclonal targets CD105
View all literature mentionsThis monoclonal targets CD117 (c-Kit)
View all literature mentionsThis monoclonal targets Ly-6G, Ly-6C
View all literature mentionsThis monoclonal targets TCR Vgamma3
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD135 (Flt3)
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.
View all literature mentions
Mus musculus with name B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1
Mus musculus with name C57BL/6N-Fgd5tm3(cre/ERT2)Djr/J from IMSR.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.
View all literature mentionsThis monoclonal targets TCR gamma/delta
View all literature mentionsThis monoclonal targets TER-119
View all literature mentionsThis monoclonal targets TCR Vgamma3
View all literature mentionsThis monoclonal targets TER-119
View all literature mentionsThis monoclonal targets Ly-6A/E
View all literature mentionsThis monoclonal targets TER-119
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets Ly-6G, Ly-6C
View all literature mentionsThis monoclonal targets CD117 (c-Kit)
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD48
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD48
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD41a
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets CD105
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD135 (Flt3)
View all literature mentionsMus musculus with name B6;129S6-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name B6;129S6-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J from IMSR.
View all literature mentions
Mus musculus with name B6.Cg-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1
Mus musculus with name C57BL/6N-Fgd5tm3(cre/ERT2)Djr/J from IMSR.
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD16/CD32
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD115
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD105
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD150
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.
View all literature mentionsThis monoclonal targets TER-119
View all literature mentionsThis monoclonal targets TER-119
View all literature mentionsThis monoclonal targets TER-119
View all literature mentionsThis monoclonal targets TCR gamma/delta
View all literature mentionsThis monoclonal targets TCR Vgamma3
View all literature mentionsThis monoclonal targets Ly-6A/E
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets CD127
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G, Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD135 (Flt3)
View all literature mentionsThis monoclonal targets F4/80
View all literature mentionsThis monoclonal targets CD117
View all literature mentionsThis monoclonal targets CD117 (c-Kit)
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD48
View all literature mentionsThis monoclonal targets CD48
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD45.1
View all literature mentionsThis monoclonal targets CD41a
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD3epsilon
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