Breast cancer 1 early onset gene codes for the DNA repair enzyme, breast cancer type 1 susceptibility protein (BRCA1). The gene is prone to mutations that cause a loss of protein function. BRCA1/Brca1 has recently been found to regulate several cellular pathways beyond DNA repair and is expressed in skeletal muscle. Skeletal muscle specific knockout of Brca1 in mice caused a loss of muscle quality, identifiable by reductions in muscle force production and mitochondrial respiratory capacity. Loss of muscle quality was associated with a shift in muscle phenotype and an accumulation of mitochondrial DNA mutations. These results demonstrate that BRCA1 is necessary for skeletal muscle function and that increased mitochondrial DNA mutations may represent a potential underlying mechanism.
Pubmed ID: 30556208 RIS Download
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This monoclonal targets Optic atrophy 1
View all literature mentionsThis polyclonal secondary targets IgG2b
View all literature mentionsThis monoclonal targets Endonuclease III-like protein 1
View all literature mentionsThis monoclonal targets TXNRD1 antibody [EPNCIR129]
View all literature mentionsThis unknown targets Human Dystrophin
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIB
View all literature mentionsThis polyclonal targets Glutathione reductase
View all literature mentionsThis polyclonal secondary targets IgM (Heavy chain)
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIA
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal targets Human DRP1, phospho (Ser616)
View all literature mentionsThis polyclonal targets TTC11
View all literature mentionsThis polyclonal targets Goat polyclonal Secondary to Rabbit IgG - H&L (HRP)
View all literature mentionsThis polyclonal targets AP endonuclease 1
View all literature mentionsThis polyclonal targets 4 Hydroxynonenal antibody
View all literature mentionsThis monoclonal targets Myosin heavy chain (slow, alpha- and beta-)
View all literature mentionsThis polyclonal targets E3 ubiquitin-protein ligase parkin phosphorylated at serine 65
View all literature mentionsThis monoclonal targets Thioredoxin reductase 2
View all literature mentionsThis unknown targets IgG1
View all literature mentionsThis monoclonal targets Mfn2
View all literature mentionsThis monoclonal targets DRP1
View all literature mentionsThis polyclonal targets 8-oxoguanine DNA glycosylase 1
View all literature mentionsThis polyclonal targets Parkin antibody
View all literature mentionsThis monoclonal targets Mfn2
View all literature mentionsThis polyclonal targets AP endonuclease 1
View all literature mentionsThis unknown targets Human Dystrophin
View all literature mentionsThis monoclonal targets Myosin heavy chain (slow, alpha- and beta-)
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIB
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIA
View all literature mentionsThis polyclonal secondary targets IgG2b
View all literature mentionsThis polyclonal targets Parkin antibody
View all literature mentionsThis polyclonal targets Glutathione reductase
View all literature mentionsThis polyclonal targets 8-oxoguanine DNA glycosylase 1
View all literature mentionsThis polyclonal targets TTC11
View all literature mentionsThis monoclonal targets Endonuclease III-like protein 1
View all literature mentionsThis polyclonal targets E3 ubiquitin-protein ligase parkin phosphorylated at serine 65
View all literature mentionsThis polyclonal secondary targets IgM (Heavy chain)
View all literature mentionsThis polyclonal targets 4 Hydroxynonenal antibody
View all literature mentionsThis unknown targets IgG1
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis monoclonal targets Optic atrophy 1
View all literature mentionsThis polyclonal targets Human DRP1, phospho (Ser616)
View all literature mentionsThis monoclonal targets Thioredoxin reductase 2
View all literature mentionsThis monoclonal targets DRP1
View all literature mentionsThis monoclonal targets TXNRD1 antibody [EPNCIR129]
View all literature mentionsThis polyclonal targets Goat polyclonal Secondary to Rabbit IgG - H&L (HRP)
View all literature mentions