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An EGF-Responsive Neural Circuit Couples Insulin Secretion with Nutrition in Drosophila.

Developmental cell | 2019

Developing organisms use fine-tuning mechanisms to adjust body growth to ever-changing nutritional conditions. In Drosophila, the secretory activity of insulin-producing cells (IPCs) is central to couple systemic growth with amino acids availability. Here, we identify a subpopulation of inhibitory neurons contacting the IPCs (IPC-connecting neurons or ICNs) that play a key role in this coupling. We show that ICNs respond to growth-blocking peptides (GBPs), a family of fat-body-derived signals produced upon availability of dietary amino acids. We demonstrate that GBPs are atypical ligands for the fly EGF receptor (EGFR). Upon activation of EGFR by adipose GBPs, ICN-mediated inhibition of IPC function is relieved, allowing insulin secretion. Our study reveals an unexpected role for EGF-like metabolic hormones and EGFR signaling as critical modulators of neural activity, coupling insulin secretion to the nutritional status.

Pubmed ID: 30555002 RIS Download

Mesh terms: Animals | Drosophila Proteins | Drosophila melanogaster | Epidermal Growth Factor | Insulin | Insulin Secretion | Insulin-Secreting Cells | Larva | Neurons | Nutritional Status

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