Mitochondria are key players in the regulation of T cell biology by dynamically responding to cell needs, but how these dynamics integrate in T cells is still poorly understood. We show here that the mitochondrial pro-fission protein Drp1 fosters migration and expansion of developing thymocytes both in vitro and in vivo. In addition, we find that Drp1 sustains in vitro clonal expansion and cMyc-dependent metabolic reprogramming upon activation, also regulating effector T cell numbers in vivo. Migration and extravasation defects are also exhibited in Drp1-deficient mature T cells, unveiling its crucial role in controlling both T cell recirculation in secondary lymphoid organs and accumulation at tumor sites. Moreover, the observed Drp1-dependent imbalance toward a memory-like phenotype favors T cell exhaustion in the tumor microenvironment. All of these findings support a crucial role for Drp1 in several processes during T cell development and in anti-tumor immune-surveillance.
Pubmed ID: 30540939 RIS Download
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View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (197G2) Rabbit mAb
View all literature mentionsThis monoclonal targets CD107a
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View all literature mentionsThis monoclonal targets p44/42 MAPK (Erk1/2)
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets AMPK-alpha, phospho (Thr172)
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View all literature mentionsThis polyclonal targets AMPK-alpha
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View all literature mentionsThis monoclonal targets CD4
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View all literature mentionsThis monoclonal targets CD38
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View all literature mentionsThis monoclonal targets CD363 (S1PR1)
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View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD54 (ICAM-1)
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View all literature mentionsThis monoclonal targets FOXP3
View all literature mentionsThis monoclonal targets H2AX (pS139)
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View all literature mentionsThis polyclonal targets Phospho-Myosin Light Chain 2 (Ser19)
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View all literature mentionsThis polyclonal targets Tom20 (FL-145)
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View all literature mentionsThis monoclonal targets DLP1
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View all literature mentionsThis monoclonal targets ATPB antibody [3D5] - Mitochondrial Marker
View all literature mentionsThis monoclonal targets CD4
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View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets OPA1
View all literature mentionsThis monoclonal targets Phospho-S6 Ribosomal Protein (Ser240/244) (D68F8) XP Rabbit mAb
View all literature mentionsThis monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (197G2) Rabbit mAb
View all literature mentionsThis monoclonal targets mTOR
View all literature mentionsThis monoclonal targets AMPK-alpha, phospho (Thr172)
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View all literature mentionsThis polyclonal targets AMPK-alpha
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View all literature mentionsThis monoclonal targets CD4
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View all literature mentionsThis monoclonal targets p44/42 MAPK (Erk1/2)
View all literature mentionsThis polyclonal targets Human DRP1, phospho (Ser616)
View all literature mentionsThis monoclonal targets CD8a
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View all literature mentionsThis polyclonal targets SMCR7L
View all literature mentionsThis monoclonal targets MFF antibody [EPR7360]
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View all literature mentionsThis monoclonal targets Mfn2
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View all literature mentionsThis monoclonal targets DLP1
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View all literature mentionsThis monoclonal targets CD8a
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View all literature mentionsThis monoclonal targets CD44
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View all literature mentionsThis monoclonal targets FOXP3
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View all literature mentionsThis monoclonal targets CD11c
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View all literature mentionsThis monoclonal targets F4/80
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View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets KLRG1
View all literature mentionsThis monoclonal targets CD127
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View all literature mentionsThis monoclonal targets TCR gamma/delta
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View all literature mentionsThis monoclonal targets CD184 (CXCR4)
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View all literature mentionsThis monoclonal targets CD69
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View all literature mentionsThis monoclonal targets CD185 (CXCR5)
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD107a
View all literature mentionsThis monoclonal targets IFN-gamma
View all literature mentionsThis monoclonal targets IL-12/IL-23
View all literature mentionsThis monoclonal targets IL-4
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD2
View all literature mentionsThis monoclonal targets TCR beta chain
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View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets CD28
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