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The number of leukocytes present in circulation varies throughout the day, reflecting bone marrow output and emigration from blood into tissues. Using an organism-wide circadian screening approach, we detected oscillations in pro-migratory factors that were distinct for specific vascular beds and individual leukocyte subsets. This rhythmic molecular signature governed time-of-day-dependent homing behavior of leukocyte subsets to specific organs. Ablation of BMAL1, a transcription factor central to circadian clock function, in endothelial cells or leukocyte subsets demonstrated that rhythmic recruitment is dependent on both microenvironmental and cell-autonomous oscillations. These oscillatory patterns defined leukocyte trafficking in both homeostasis and inflammation and determined detectable tumor burden in blood cancer models. Rhythms in the expression of pro-migratory factors and migration capacities were preserved in human primary leukocytes. The definition of spatial and temporal expression profiles of pro-migratory factors guiding leukocyte migration patterns to organs provides a resource for the further study of the impact of circadian rhythms in immunity.
Pubmed ID: 30527911 RIS Download
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Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsCommercial supplier and developer of in vivo antibodies. Provides antibodies and antibody production services.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.
View all literature mentionsA healthcare company that provides biomedical solutions and diagnostic and preclinical systems to life science professionals.
View all literature mentionsCommercial organism provider selling mice, rats and other model animals. American corporation specializing in a variety of pre-clinical and clinical laboratory services for the pharmaceutical, medical device and biotechnology industries. It also supplies assorted biomedical products and research and development outsourcing services for use in the pharmaceutical industry. (Wikipedia)
View all literature mentionsAn independent, nonprofit organization focused on mammalian genetics research to advance human health. Their mission is to discover the genetic basis for preventing, treating, and curing human disease, and to enable research for the global biomedical community. Jackson Laboratory breeds and manages colonies of mice as resources for other research institutions and laboratories, along with providing software and techniques. Jackson Lab also conducts genetic research and provides educational material for various educational levels.
View all literature mentionsA commercial organization which provides assay technologies to isolate DNA, RNA, and proteins from any biological sample. Assay technologies are then used to make specific target biomolecules, such as the DNA of a specific virus, visible for subsequent analysis.
View all literature mentionsAn Organization portal, Antibody supplier, Service resource,
View all literature mentionslaboratory mouse with name C57BL/6N from MGI.
View all literature mentionsCell line HUVEC-C is a Finite cell line with a species of origin Homo sapiens
View all literature mentionsCell line NALM-6 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis monoclonal targets CD49d
View all literature mentionsThis monoclonal targets CD106
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis monoclonal targets CD185
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD102
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis monoclonal targets CD11a
View all literature mentionsThis monoclonal targets CD183
View all literature mentionsThis monoclonal targets L-Selectin (CD62L)
View all literature mentionsThis monoclonal targets CD56
View all literature mentionsThis monoclonal targets CD29
View all literature mentionsThis monoclonal targets MAdCAM-1
View all literature mentionsThis monoclonal targets CD16
View all literature mentionsThis monoclonal targets CD193
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD115
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets I-A/I-E
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets VLA-4 (CD49d)
View all literature mentionsThis monoclonal targets NK1.1
View all literature mentionsThis monoclonal targets LFA-1α (CD11a)
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD106 (VCAM-1)
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD49f
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD199
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD49d
View all literature mentionsThis monoclonal targets CD54
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD62P (P-Selectin)
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis isotype control targets KLH
View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets PSGL-1 (CD162)
View all literature mentionsThis monoclonal targets CD14
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets CD195
View all literature mentionsThis monoclonal targets CX3CR1
View all literature mentionsThis monoclonal targets CD3
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View all literature mentionsThis monoclonal targets CD197
View all literature mentionsThis isotype control targets Trinitrophenol
View all literature mentionsThis monoclonal targets CD18
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View all literature mentionsThis monoclonal targets CD196
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis monoclonal targets CD193
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD115
View all literature mentionsThis monoclonal targets CD49b
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD54 (ICAM-1)
View all literature mentionsThis monoclonal targets CD29
View all literature mentionsThis monoclonal targets CD194
View all literature mentionsThis monoclonal targets CD8a
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View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis isotype control targets KLH
View all literature mentionsThis isotype control targets Trinitrophenol
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets NK1.1
View all literature mentionsThis monoclonal targets CD115
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD115
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD193
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD194
View all literature mentionsThis monoclonal targets CD196
View all literature mentionsThis monoclonal targets CD193
View all literature mentionsThis monoclonal targets CD195
View all literature mentionsThis monoclonal targets CD197
View all literature mentionsThis monoclonal targets I-A/I-E
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD11a
View all literature mentionsThis monoclonal targets CD49b
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View all literature mentionsThis monoclonal targets CD185
View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis monoclonal targets CD183
View all literature mentionsThis monoclonal targets CD3epsilon
View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis monoclonal targets CD199
View all literature mentionsThis monoclonal targets CX3CR1
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View all literature mentionsThis monoclonal targets CD14
View all literature mentionsThis monoclonal targets CD115
View all literature mentionsThis monoclonal targets CD11c
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View all literature mentionsThis monoclonal targets CD8a
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View all literature mentionsThis monoclonal targets CD102
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
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View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis monoclonal targets Ly-6G Ly-6C
View all literature mentionsThis monoclonal targets CD115
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View all literature mentionsThis monoclonal targets CD56
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View all literature mentionsThis monoclonal targets CD106 (VCAM-1)
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View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets MAdCAM-1
View all literature mentionsThis monoclonal targets CD54
View all literature mentionsThis monoclonal targets CD45R
View all literature mentionsThis monoclonal targets CD62P (P-Selectin)
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets NK1.1
View all literature mentionsThis monoclonal targets CD29
View all literature mentionsThis monoclonal targets L-Selectin (CD62L)
View all literature mentionsThis monoclonal targets CD18
View all literature mentionsThis monoclonal targets LFA-1α (CD11a)
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets CD54 (ICAM-1)
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis isotype control targets KLH
View all literature mentionsThis isotype control targets HRP
View all literature mentionsThis isotype control targets Trinitrophenol
View all literature mentionsThis monoclonal targets VLA-4 (CD49d)
View all literature mentionsThis monoclonal targets PSGL-1 (CD162)
View all literature mentionsThis monoclonal targets LFA-1α (CD11a)
View all literature mentionsThis monoclonal targets VLA-4 (CD49d)
View all literature mentionsThis monoclonal targets CD29
View all literature mentionsThis monoclonal targets CD18
View all literature mentionsThis monoclonal targets PSGL-1 (CD162)
View all literature mentionsThis monoclonal targets L-Selectin (CD62L)
View all literature mentionsThis monoclonal targets CD106 (VCAM-1)
View all literature mentionsThis monoclonal targets CD54 (ICAM-1)
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets PNAd
View all literature mentionsThis monoclonal targets CD62P (P-Selectin)
View all literature mentionsThis monoclonal targets CD102
View all literature mentionsThis monoclonal targets MAdCAM-1
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD106
View all literature mentionsThis monoclonal targets CD49d
View all literature mentionsThis monoclonal targets CD54
View all literature mentionsThis monoclonal targets CD16
View all literature mentionsThis monoclonal targets CD14
View all literature mentionsThis monoclonal targets CD56
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD49f
View all literature mentionsThis monoclonal targets CD49d
View all literature mentionsThis monoclonal targets CD49b
View all literature mentionsThis monoclonal targets CD29
View all literature mentionsThis monoclonal targets CD11a
View all literature mentionsThis monoclonal targets CX3CR1
View all literature mentionsThis monoclonal targets CD185
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis monoclonal targets CD184
View all literature mentionsThis monoclonal targets CD183
View all literature mentionsThis monoclonal targets CD199
View all literature mentionsThis monoclonal targets CD197
View all literature mentionsThis monoclonal targets CD195
View all literature mentionsThis monoclonal targets CD194
View all literature mentionsThis monoclonal targets CD196
View all literature mentionsThis monoclonal targets I-A/I-E
View all literature mentionsThis monoclonal targets CD193
View all literature mentionsThis monoclonal targets CD193
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD45.2
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