Searching across hundreds of databases
Type I and type III interferons (IFNs) are critical for controlling viral infections. However, the precise dynamics of the IFN response have been difficult to define in vivo. Signaling through type I IFN receptors leads to interferon-stimulated response element (ISRE)-dependent gene expression and an antiviral state. As an alternative to tracking IFN, we used an ISRE-dependent reporter mouse to define the cell types, localization, and kinetics of IFN responding cells during influenza virus infection. We find that measurable IFN responses are largely limited to hematopoietic cells, which show a high sensitivity to IFN. Inflammatory monocytes display high basal IFN responses, which are enhanced upon infection and correlate with infection of these cells. We find that inflammatory monocyte development is independent of IFN signaling; however, IFN is critical for chemokine production and recruitment following infection. The data reveal a role for inflammatory monocytes in both basal IFN responses and responses to infection.
Pubmed ID: 30517866 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Mus musculus with name C57BL/6J from IMSR.
View all literature mentionsCell line MDCK is a Spontaneously immortalized cell line with a species of origin Canis lupus familiaris
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Siglec-F
View all literature mentionsThis monoclonal targets Mouse/Rat CCR2 Allophycocyanin MAb (Clone 475301)
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD103 (Integrin alpha E)
View all literature mentionsThis monoclonal targets CD45R/B220
View all literature mentionsThis monoclonal targets Mouse CD11c
View all literature mentionsThis monoclonal targets CD178 (Fas Ligand)
View all literature mentionsThis monoclonal targets beta-Actin
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets Mouse CD11c
View all literature mentionsThis monoclonal targets CD31 (PECAM-1)
View all literature mentionsThis monoclonal targets Nucleoprotein
View all literature mentionsThis monoclonal targets Mouse Ly-6C
View all literature mentionsThis monoclonal targets CD326 (EpCAM)
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets Mouse CD11c
View all literature mentionsThis monoclonal targets Siglec-F
View all literature mentionsThis monoclonal targets CD31 (PECAM-1)
View all literature mentionsThis monoclonal targets Mouse Ly-6C
View all literature mentionsThis monoclonal targets CD45R/B220
View all literature mentionsThis monoclonal targets NK-1.1
View all literature mentionsThis monoclonal targets Mouse CD11c
View all literature mentionsThis monoclonal targets Mouse/Rat CCR2 Allophycocyanin MAb (Clone 475301)
View all literature mentionsThis monoclonal targets beta-Actin
View all literature mentionsThis monoclonal targets CD178 (Fas Ligand)
View all literature mentionsThis monoclonal targets Nucleoprotein
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD326 (EpCAM)
View all literature mentionsThis monoclonal targets CD103 (Integrin alpha E)
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
