The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process, which rapidly generates the myelin sheath. Once formed, the mSC transitions to a stable homeostatic state, with loss of this stability associated with neuropathies. The histone deacetylases histone deacetylase 1 (HDAC1) and HDAC2 are required for the myelination transcriptional program. Here, we show a distinct role for HDAC3, in that, while dispensable for the formation of mSCs, it is essential for the stability of the myelin sheath once formed-with loss resulting in progressive severe neuropathy in adulthood. This is associated with the prior failure to downregulate the biogenic program upon entering the homeostatic state leading to hypertrophy and hypermyelination of the mSCs, progressing to the development of severe myelination defects. Our results highlight distinct roles of HDAC1/2 and HDAC3 in controlling the differentiation and homeostatic states of a cell with broad implications for the understanding of this important cell-state transition.
Pubmed ID: 30517863 RIS Download
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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.
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View all literature mentionsThis polyclonal secondary targets IgG (H+L)
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View all literature mentionsThis polyclonal targets Chicken IgY
View all literature mentionsThis polyclonal targets Myelin Protein Zero
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View all literature mentionsThis monoclonal targets HDAC2
View all literature mentionsThis monoclonal targets HDAC2
View all literature mentionsThis monoclonal secondary targets IgG
View all literature mentionsThis polyclonal targets 200 kD Neurofilament Heavy - Neuronal Marker
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Mus musculus with name B6Brd;B6N-Tyrc-Brd Hdac3
Rattus norvegicus with name Crl:CD(SD) from RGD.
View all literature mentionsRattus norvegicus with name Crl:CD(SD) from RGD.
View all literature mentionsThis polyclonal secondary targets IgY (H+L)
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis monoclonal secondary targets IgG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets Chicken IgY
View all literature mentionsThis polyclonal targets HSPA5
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets Myelin Protein Zero
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets Nerve Growth Factor Receptor (NGF-Receptor), p75
View all literature mentionsThis polyclonal targets MAP Kinase (ERK-1 ERK-2) antibody produced in rabbit
View all literature mentionsThis monoclonal targets S-100 (beta-Subunit)
View all literature mentionsThis monoclonal targets RAT ANTI MOUSE F4/80
View all literature mentionsThis monoclonal targets Akt, phospho (Ser473)
View all literature mentionsThis monoclonal targets Phospho-Akt (Thr308) (C31E5E) Rabbit mAb
View all literature mentionsThis polyclonal targets S100 isolated from cow brain.
View all literature mentionsThis unknown targets Widely expressed. Synthetic peptide: C-NEFYDGDHDNDKESDVEI conjugated to KLH, corresponding to amino acids 411-428 of Human HDAC3.
View all literature mentionsThis monoclonal targets HDAC2
View all literature mentionsThis polyclonal targets HDAC1 - ChIP Grade
View all literature mentionsThis monoclonal targets 129/Sv mouse-derived endothelioma cell line tEnd.1
View all literature mentionsThis monoclonal targets HDAC2
View all literature mentionsThis polyclonal targets Nerve Growth Factor Receptor (NGF-Receptor), p75
View all literature mentionsThis polyclonal targets Nerve Growth Factor Receptor (NGF-Receptor), p75
View all literature mentionsThis polyclonal targets 200 kD Neurofilament Heavy - Neuronal Marker
View all literature mentions
Mus musculus with name B6Brd;B6N-Tyrc-Brd Hdac3
This polyclonal targets 200 kD Neurofilament Heavy - Neuronal Marker
View all literature mentionsThis polyclonal secondary targets IgY (H+L)
View all literature mentionsThis unknown targets IgG
View all literature mentionsRattus norvegicus with name Crl:CD(SD) from RGD.
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets HSPA5
View all literature mentionsThis polyclonal targets Nerve Growth Factor Receptor (NGF-Receptor), p75
View all literature mentionsThis monoclonal secondary targets IgG
View all literature mentionsThis polyclonal targets Chicken IgY
View all literature mentionsThis polyclonal targets Myelin Protein Zero
View all literature mentionsThis monoclonal targets Akt, phospho (Ser473)
View all literature mentionsThis monoclonal targets Phospho-Akt (Thr308) (C31E5E) Rabbit mAb
View all literature mentionsThis polyclonal targets MAP Kinase (ERK-1 ERK-2) antibody produced in rabbit
View all literature mentionsThis monoclonal targets RAT ANTI MOUSE F4/80
View all literature mentionsThis polyclonal targets Nerve Growth Factor Receptor (NGF-Receptor), p75
View all literature mentionsThis monoclonal targets S-100 (beta-Subunit)
View all literature mentionsThis monoclonal targets 129/Sv mouse-derived endothelioma cell line tEnd.1
View all literature mentionsThis polyclonal targets S100 isolated from cow brain.
View all literature mentionsThis polyclonal targets HDAC1 - ChIP Grade
View all literature mentionsThis unknown targets Widely expressed. Synthetic peptide: C-NEFYDGDHDNDKESDVEI conjugated to KLH, corresponding to amino acids 411-428 of Human HDAC3.
View all literature mentionsThis monoclonal targets HDAC2
View all literature mentionsThis monoclonal targets HDAC2
View all literature mentions