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Diabetic kidney disease (DKD) is a major complication of diabetes. We found that UTX (ubiquitously transcribed tetratricopeptide repeat on chromosome X, also known as KDM6A), a histone demethylase, was upregulated in the renal mesangial and tubular cells of diabetic mice and DKD patients. In cultured renal mesangial and tubular cells, UTX overexpression promoted palmitic acid-induced elevation of inflammation and DNA damage, whereas UTX knockdown or GSK-J4 treatment showed the opposite effects. We found that UTX demethylase activity-dependently regulated the transcription of inflammatory genes and apoptosis; moreover, UTX bound with p53 and p53-dependently exacerbated DNA damage. Administration of GSK-J4, an H3K27 demethylase inhibitor, ameliorated the diabetes-induced renal abnormalities in db/db mice, an animal model of type 2 diabetes. These results revealed the possible mechanisms underlying the regulation of histone methylation in DKD and suggest UTX as a potential therapeutic target for DKD.
Pubmed ID: 30516825 RIS Download
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This monoclonal targets Bcl-2
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View all literature mentionsThis polyclonal targets KDM6A / UTX
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View all literature mentionsThis monoclonal targets Histone H2A.X, phospho (Ser139)
View all literature mentionsThis unknown targets Raised against a peptide mapping at the amino terminus of Bax of mouse origin
View all literature mentionsThis monoclonal targets Chk1, phospho (Ser345)
View all literature mentionsThis monoclonal targets UTX
View all literature mentionsThis polyclonal targets H3K27me2
View all literature mentionsThis unknown targets Collagen Type IV Antibody
View all literature mentionsThis monoclonal targets Histone H3 (tri methyl K27) antibody [mAbcam 6002] - ChIP Grade
View all literature mentionsThis monoclonal targets Actin, α-Smooth Muscle
View all literature mentionsThis polyclonal targets ATR, phospho (Ser428)
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View all literature mentionsThis polyclonal targets H3K27me3
View all literature mentionsThis polyclonal targets H3K27me2
View all literature mentionsThis monoclonal targets Chk1, phospho (Ser345)
View all literature mentionsThis monoclonal targets UTX
View all literature mentionsThis monoclonal targets Histone H2A.X, phospho (Ser139)
View all literature mentionsThis monoclonal targets Actin, α-Smooth Muscle
View all literature mentionsThis polyclonal targets Histone H3
View all literature mentionsThis monoclonal targets beta-Actin
View all literature mentionsThis monoclonal targets Bcl-2
View all literature mentionsThis polyclonal targets Phospho-p53 (Ser15)
View all literature mentionsThis unknown targets Raised against a peptide mapping at the amino terminus of Bax of mouse origin
View all literature mentionsThis monoclonal targets ATM protein
View all literature mentionsThis polyclonal targets ATR, phospho (Ser428)
View all literature mentionsThis monoclonal targets Histone H3 (tri methyl K27) antibody [mAbcam 6002] - ChIP Grade
View all literature mentionsThis monoclonal targets EMR1
View all literature mentionsThis polyclonal targets KDM6A / UTX
View all literature mentionsThis unknown targets Collagen Type IV Antibody
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
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