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The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.

British journal of pharmacology | 2019

The pathogenic mechanism of autosomal dominant polycystic kidney disease (ADPKD) is unclear. Similar to tumour cells, polycystic kidney cells are primarily dependent on aerobic glycolysis for ATP production. Compared with rodents, miniature pigs are more similar to humans. This study is the first time to investigate the effects of the combination of metformin and 2-deoxyglucose (2DG) in a pig model of chronic progressive ADPKD.

Pubmed ID: 30515768 RIS Download

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This is a list of tools and resources that we have found mentioned in this publication.


Hexokinase 1 antibody (antibody)

RRID:AB_10859778

This polyclonal targets Hexokinase 1

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Phospho-PKA C (Thr197) Antibody (antibody)

RRID:AB_2300165

This polyclonal targets Phospho-PKA C (Thr197)

View all literature mentions

CDK2 (78B2) Rabbit mAb (antibody)

RRID:AB_2276129

This monoclonal targets CDK2 (78B2) Rabbit mAb

View all literature mentions

Anti-β-Actin Antibody (antibody)

RRID:AB_476744

This monoclonal targets slightly modified β-cytoplasmic actin N-terminal peptide, Ac-Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys, conjugated to KLH

View all literature mentions

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb (antibody)

RRID:AB_331772

This monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)

View all literature mentions

Phospho-p70 S6 Kinase (Thr389) (1A5) Mouse mAb (antibody)

RRID:AB_2285392

This monoclonal targets p70 S6 Kinase, phospho (Thr389)

View all literature mentions

Phospho-mTOR (Ser2448) Antibody (antibody)

RRID:AB_330970

This polyclonal targets Phospho-mTOR (Ser2448)

View all literature mentions

Phospho-c-Raf (Ser259) Antibody (antibody)

RRID:AB_330759

This polyclonal targets Phospho-c-Raf (Ser259)

View all literature mentions

SDHA antibody (antibody)

RRID:AB_11182164

This polyclonal targets SDHA

View all literature mentions

Phospho-4E-BP1 (Ser65) Antibody (antibody)

RRID:AB_330947

This polyclonal targets Phospho-4E-BP1 (Ser65)

View all literature mentions

CDK6 (D4S8S) Rabbit mAb (antibody)

RRID:AB_2721897

This monoclonal targets CDK6

View all literature mentions

Phospho-AMPKα (Thr172) Antibody (antibody)

RRID:AB_330330

This polyclonal targets Phospho-AMPKα (Thr172)

View all literature mentions

PKM antibody (antibody)

RRID:AB_2283775

This polyclonal targets PKM

View all literature mentions

PCNA (PC10) Mouse mAb (antibody)

RRID:AB_2160343

This monoclonal targets PCNA

View all literature mentions

ImageJ (software resource)

RRID:SCR_003070

Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.

View all literature mentions

SPSS (software resource)

RRID:SCR_002865

Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.

View all literature mentions

Phospho-c-Raf (Ser259) Antibody (antibody)

RRID:AB_330759

This polyclonal targets Phospho-c-Raf (Ser259)

View all literature mentions

Phospho-AMPKα (Thr172) Antibody (antibody)

RRID:AB_330330

This polyclonal targets Phospho-AMPKα (Thr172)

View all literature mentions

SPSS (software resource)

RRID:SCR_002865

Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.

View all literature mentions

ImageJ (software resource)

RRID:SCR_003070

Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.

View all literature mentions

Anti-β-Actin Antibody (antibody)

RRID:AB_476744

This monoclonal targets slightly modified β-cytoplasmic actin N-terminal peptide, Ac-Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys, conjugated to KLH

View all literature mentions

SDHA antibody (antibody)

RRID:AB_11182164

This polyclonal targets SDHA

View all literature mentions

PKM antibody (antibody)

RRID:AB_2283775

This polyclonal targets PKM

View all literature mentions

Hexokinase 1 antibody (antibody)

RRID:AB_10859778

This polyclonal targets Hexokinase 1

View all literature mentions

CDK6 (D4S8S) Rabbit mAb (antibody)

RRID:AB_2721897

This monoclonal targets CDK6

View all literature mentions

CDK2 (78B2) Rabbit mAb (antibody)

RRID:AB_2276129

This monoclonal targets CDK2 (78B2) Rabbit mAb

View all literature mentions

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb (antibody)

RRID:AB_331772

This monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)

View all literature mentions

Phospho-PKA C (Thr197) Antibody (antibody)

RRID:AB_2300165

This polyclonal targets Phospho-PKA C (Thr197)

View all literature mentions

Phospho-4E-BP1 (Ser65) Antibody (antibody)

RRID:AB_330947

This polyclonal targets Phospho-4E-BP1 (Ser65)

View all literature mentions

Phospho-p70 S6 Kinase (Thr389) (1A5) Mouse mAb (antibody)

RRID:AB_2285392

This monoclonal targets p70 S6 Kinase, phospho (Thr389)

View all literature mentions

Phospho-mTOR (Ser2448) Antibody (antibody)

RRID:AB_330970

This polyclonal targets Phospho-mTOR (Ser2448)

View all literature mentions

PCNA (PC10) Mouse mAb (antibody)

RRID:AB_2160343

This monoclonal targets PCNA

View all literature mentions

Phospho-c-Raf (Ser259) Antibody (antibody)

RRID:AB_330759

This polyclonal targets Phospho-c-Raf (Ser259)

View all literature mentions

Phospho-AMPKα (Thr172) Antibody (antibody)

RRID:AB_330330

This polyclonal targets Phospho-AMPKα (Thr172)

View all literature mentions

SPSS (software resource)

RRID:SCR_002865

Software package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.

View all literature mentions

ImageJ (software resource)

RRID:SCR_003070

Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.

View all literature mentions

Anti-β-Actin Antibody (antibody)

RRID:AB_476744

This monoclonal targets slightly modified β-cytoplasmic actin N-terminal peptide, Ac-Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys, conjugated to KLH

View all literature mentions

SDHA antibody (antibody)

RRID:AB_11182164

This polyclonal targets SDHA

View all literature mentions

PKM antibody (antibody)

RRID:AB_2283775

This polyclonal targets PKM

View all literature mentions

Hexokinase 1 antibody (antibody)

RRID:AB_10859778

This polyclonal targets Hexokinase 1

View all literature mentions

CDK6 (D4S8S) Rabbit mAb (antibody)

RRID:AB_2721897

This monoclonal targets CDK6

View all literature mentions

CDK2 (78B2) Rabbit mAb (antibody)

RRID:AB_2276129

This monoclonal targets CDK2 (78B2) Rabbit mAb

View all literature mentions

Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (20G11) Rabbit mAb (antibody)

RRID:AB_331772

This monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)

View all literature mentions

Phospho-PKA C (Thr197) Antibody (antibody)

RRID:AB_2300165

This polyclonal targets Phospho-PKA C (Thr197)

View all literature mentions

Phospho-4E-BP1 (Ser65) Antibody (antibody)

RRID:AB_330947

This polyclonal targets Phospho-4E-BP1 (Ser65)

View all literature mentions

Phospho-p70 S6 Kinase (Thr389) (1A5) Mouse mAb (antibody)

RRID:AB_2285392

This monoclonal targets p70 S6 Kinase, phospho (Thr389)

View all literature mentions

Phospho-mTOR (Ser2448) Antibody (antibody)

RRID:AB_330970

This polyclonal targets Phospho-mTOR (Ser2448)

View all literature mentions

PCNA (PC10) Mouse mAb (antibody)

RRID:AB_2160343

This monoclonal targets PCNA

View all literature mentions