Gene regulation of multipotent neuroretinal progenitors is partially understood. Through characterizing Six3 and Six6 double knockout retinas (DKOs), we demonstrate Six3 and Six6 are jointly required for the maintenance of multipotent neuroretinal progenitors. Phenotypes in DKOs were not found in either Six3 nulls or Six6 nulls. At the far periphery, ciliary margin (CM) markers Otx1 and Cdon together with Wnt3a and Fzd1 were ectopically upregulated, whereas neuroretinal progenitor markers Sox2, Notch1, and Otx2 were absent or reduced. At the mid periphery, multi-lineage differentiation was defective. The gene set jointly regulated by Six3 and Six6 significantly overlapped with the gene networks regulated by WNT3A, CTNNB1, POU4F2, or SOX2. Stimulation of Wnt/β-catenin signaling by either Wnt-3a or a GS3Kβ inhibitor promoted CM progenitors at the cost of neuroretinal identity at the periphery of eyecups. Therefore, Six3 and Six6 together directly or indirectly suppress Wnt/β-catenin signaling but promote retinogenic factors for the maintenance of multipotent neuroretinal progenitors.
Pubmed ID: 30485816 RIS Download
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A contract research organization providing drug development and animal testing services. Under the name Covance Research Products Inc., based in Denver, Pennsylvania, the company also deals in the import, breeding and sale of laboratory animals. It breeds dogs, rabbits, guinea pigs, non-human primates, and pigs, and runs the largest non-human primate laboratory in Germany. (Wikipedia)
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on February 28,2023. Software Python package that provides infrastructure to process data from high-throughput sequencing assays. While the main purpose of HTSeq is to allow you to write your own analysis scripts, customized to your needs, there are also a couple of stand-alone scripts for common tasks that can be used without any Python knowledge.
View all literature mentionsA commercial organization which provides assay technologies to isolate DNA, RNA, and proteins from any biological sample. Assay technologies are then used to make specific target biomolecules, such as the DNA of a specific virus, visible for subsequent analysis.
View all literature mentionsA web-based software application that enables users to analyze, integrate, and understand data derived from gene expression, microRNA, and SNP microarrays, metabolomics, proteomics, and RNA-Seq experiments, and small-scale experiments that generate gene and chemical lists. Users can search for targeted information on genes, proteins, chemicals, and drugs, and build interactive models of experimental systems. IPA allows exploration of molecular, chemical, gene, protein and miRNA interactions, creation of custom molecular pathways, and the ability to view and modify metabolic, signaling, and toxicological canonical pathways. In addition to the networks and pathways that can be created, IPA can provide multiple layering of additional information, such as drugs, disease genes, expression data, cellular functions and processes, or a researchers own genes or chemicals of interest.
View all literature mentionsA commercial antibody supplier which supplies primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits.
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View all literature mentionsThis polyclonal targets Cone Arrestin
View all literature mentionsThis polyclonal targets Choline Acetyltransferase
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View all literature mentionsThis unknown targets phospho-Histone H3 (Ser10)
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View all literature mentionsThis polyclonal targets Glycine Transporter 1, Glial (GLYT1)
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View all literature mentionsMus musculus with name B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J from IMSR.
View all literature mentionsThis polyclonal targets Tyrosine Hydroxylase
View all literature mentionsThis polyclonal targets Neurofilament M
View all literature mentionsThis polyclonal targets Glycine Transporter 1, Glial (GLYT1)
View all literature mentionsThis polyclonal targets Tyrosine Hydroxylase
View all literature mentionsThis polyclonal targets Neurofilament M
View all literature mentionsThis polyclonal targets Glycine Transporter 1, Glial (GLYT1)
View all literature mentionsThis polyclonal targets Tyrosine Hydroxylase
View all literature mentionsThis polyclonal targets GABA B Receptor 1 antibody
View all literature mentionsThis polyclonal targets Tyrosine Hydroxylase
View all literature mentionsThis polyclonal targets PKCZ
View all literature mentionsThis monoclonal targets Rhodopsin antibody [Rho 4D2]
View all literature mentionsThis polyclonal targets Chx10 N-terminus
View all literature mentionsThis monoclonal targets Neuronal Class III beta-Tubulin (TUJ1) Purified
View all literature mentionsThis polyclonal targets Glial Fibrillary Acidic Protein
View all literature mentionsThis monoclonal targets Laminin-1 A&B Chains, cross region
View all literature mentionsThis polyclonal targets Neurofilament M
View all literature mentionsThis polyclonal targets Glycine Transporter 1, Glial (GLYT1)
View all literature mentionsMus musculus with name B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J from IMSR.
View all literature mentionsThis unknown targets
View all literature mentionsThis unknown targets GABA
View all literature mentionsThis polyclonal targets Choline Acetyltransferase
View all literature mentionsThis monoclonal targets GAD65
View all literature mentionsThis monoclonal targets Neuronal Class III beta-Tubulin (TUJ1) Purified
View all literature mentionsThis polyclonal targets GABA B Receptor 1 antibody
View all literature mentionsThis unknown targets phospho-Histone H3 (Ser10)
View all literature mentionsThis monoclonal targets Rhodopsin antibody [Rho 4D2]
View all literature mentionsThis polyclonal targets Pax-6
View all literature mentionsThis polyclonal targets PKCZ
View all literature mentionsThis polyclonal targets Human Otx2 Affinity Purified Ab
View all literature mentionsThis polyclonal targets Tyrosine Hydroxylase
View all literature mentionsThis polyclonal targets Chx10 N-terminus
View all literature mentionsMus musculus with name B6.Cg-Tg(CAG-cre/Esr1*)5Amc/J from IMSR.
View all literature mentionsThis polyclonal targets Pax-6
View all literature mentionsThis unknown targets phospho-Histone H3 (Ser10)
View all literature mentionsThis polyclonal targets Human Otx2 Affinity Purified Ab
View all literature mentionsThis polyclonal targets Neurofilament M
View all literature mentionsThis polyclonal targets Glycine Transporter 1, Glial (GLYT1)
View all literature mentionsThis monoclonal targets Laminin-1 A&B Chains, cross region
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets Glial Fibrillary Acidic Protein
View all literature mentionsThis unknown targets GABA
View all literature mentionsThis monoclonal targets GAD65
View all literature mentionsThis polyclonal targets Choline Acetyltransferase
View all literature mentions