Recent investigations have demonstrated an important role of gut microbiota (GM) in the pathogenesis of Alzheimer's disease (AD). GM modulates a host's health and disease by production of several substances, including lipopolysaccharides (LPS) and short-chain fatty acids (SCFAs), among others. Diet can modify the composition and diversity of GM, and ingestion of a healthy diet has been suggested to lower the risk to develop AD. We have previously shown that bioactive food (BF) ingestion can abate neuroinflammation and oxidative stress and improve cognition in obese rats, effects associated with GM composition. Therefore, BF can impact the gut-brain axis and improved behavior. In this study, we aim to explore if inclusion of BF in the diet may impact central pathological markers of AD by modulation of the GM. Triple transgenic 3xTg-AD (TG) female mice were fed a combination of dried nopal, soy, chia oil, and turmeric for 7 months. We found that BF ingestion improved cognition and reduced Aβ aggregates and tau hyperphosphorylation. In addition, BF decreased MDA levels, astrocyte and microglial activation, PSD-95, synaptophysin, GluR1 and ARC protein levels in TG mice. Furthermore, TG mice fed BF showed increased levels of pGSK-3β. GM analysis revealed that pro-inflammatory bacteria were more abundant in TG mice compared to wild-type, while BF ingestion was able to restore the GM's composition, LPS, and propionate levels to control values. Therefore, the neuroprotective effects of BF may be mediated, in part, by modulation of GM and the release of neurotoxic substances that alter brain function.
Pubmed ID: 30475761 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This monoclonal targets Phospho-Tau (Thr231)
View all literature mentionsThis monoclonal targets Tau
View all literature mentionsThis polyclonal targets GSK3B
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal targets Iba1
View all literature mentionsThis monoclonal targets PSD-95
View all literature mentionsThis polyclonal targets Malondialdehyde
View all literature mentionsThis polyclonal targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets FFAR3
View all literature mentionsThis monoclonal targets Phospho-Tau (Thr212, Ser214)
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis monoclonal targets Syp
View all literature mentionsThis monoclonal targets GluR1 [E308] antibody
View all literature mentionsThis polyclonal targets Phospho-GSK-3alpha/beta (Ser21/9)
View all literature mentionsThis monoclonal targets PRKAA1, PRKAA2
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets Prkaa2
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis monoclonal targets GFAP
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsMus musculus with name B6;129-Tg(APPSwe,tauP301L)1Lfa Psen1tm1Mpm/Mmjax from MMRRC.
View all literature mentionsMus musculus with name B6129SF1/J from IMSR.
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets Phospho-Tau (Thr231)
View all literature mentionsThis monoclonal targets Syp
View all literature mentionsThis monoclonal targets PSD-95
View all literature mentionsThis monoclonal targets Phospho-Tau (Thr212, Ser214)
View all literature mentionsThis monoclonal targets PRKAA1, PRKAA2
View all literature mentionsThis polyclonal targets Prkaa2
View all literature mentionsMus musculus with name B6129SF1/J from IMSR.
View all literature mentionsMus musculus with name B6;129-Tg(APPSwe,tauP301L)1Lfa Psen1tm1Mpm/Mmjax from MMRRC.
View all literature mentionsThis polyclonal targets Malondialdehyde
View all literature mentionsThis polyclonal targets Iba1
View all literature mentionsThis monoclonal targets Tau
View all literature mentionsThis polyclonal targets GSK3B
View all literature mentionsThis polyclonal targets Phospho-GSK-3alpha/beta (Ser21/9)
View all literature mentionsThis monoclonal targets GluR1 [E308] antibody
View all literature mentionsThis monoclonal targets GFAP
View all literature mentionsThis polyclonal targets FFAR3
View all literature mentions