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Publication

Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State.

Cell metabolism | 2019

Understanding the neural framework behind appetite control is fundamental to developing effective therapies to combat the obesity epidemic. The paraventricular hypothalamus (PVH) is critical for appetite regulation, yet, the real-time, physiological response properties of PVH neurons to nutrients are unknown. Using a combination of fiber photometry, electrophysiology, immunohistochemistry, and neural manipulation strategies, we determined the population dynamics of four molecularly delineated PVH subsets implicated in feeding behavior: glucagon-like peptide 1 receptor (PVHGlp1r), melanocortin-4 receptor (PVHMc4r), oxytocin (PVHOxt), and corticotropin-releasing hormone (PVHCrh). We identified both calorie- and state-dependent sustained activity increases and decreases in PVHGlp1r and PVHCrh populations, respectively, while observing transient bulk changes of PVHMc4r, but no response in PVHOxt, neurons to food. Furthermore, we highlight the role of PVHGlp1r neurons in orchestrating acute feeding behavior, independent of the anti-obesity drug liraglutide, and demonstrate the indispensability of PVHGlp1r and PVHMc4r, but not PVHOxt or PVHCrh neurons, in body weight maintenance.

Pubmed ID: 30472090 RIS Download

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Associated grants

Agency: Intramural NIH HHS, United States
Id: ZIA DK075087-02
Agency: Intramural NIH HHS, United States
Id: ZIA DK075087-01
Agency: NIDDK NIH HHS, United States
Id: R01 DK104999
Agency: NIDDK NIH HHS, United States
Id: P30 DK020572
Agency: Intramural NIH HHS, United States
Id: Z99 DK999999
Agency: NIDDK NIH HHS, United States
Id: R56 DK104999
Agency: NIDDK NIH HHS, United States
Id: R01 DK103703

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