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Drosophila Dpr (21 paralogs) and DIP proteins (11 paralogs) are cell recognition molecules of the immunoglobulin superfamily (IgSF) that form a complex protein interaction network. DIP and Dpr proteins are expressed in a synaptic layer-specific fashion in the visual system. How interactions between these proteins regulate layer-specific synaptic circuitry is not known. Here we establish that DIP-α and its interacting partners Dpr6 and Dpr10 regulate multiple processes, including arborization within layers, synapse number, layer specificity, and cell survival. We demonstrate that heterophilic binding between Dpr6/10 and DIP-α and homophilic binding between DIP-α proteins promote interactions between processes in vivo. Knockin mutants disrupting the DIP/Dpr binding interface reveal a role for these proteins during normal development, while ectopic expression studies support an instructive role for interactions between DIPs and Dprs in circuit development. These studies support an important role for the DIP/Dpr protein interaction network in regulating cell-type-specific connectivity patterns.
Pubmed ID: 30467079 RIS Download
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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.
View all literature mentionsDatabase of Drosophila genetic and genomic information with information about stock collections and fly genetic tools. Gene Ontology (GO) terms are used to describe three attributes of wild-type gene products: their molecular function, the biological processes in which they play a role, and their subcellular location. Additionally, FlyBase accepts data submissions. FlyBase can be searched for genes, alleles, aberrations and other genetic objects, phenotypes, sequences, stocks, images and movies, controlled terms, and Drosophila researchers using the tools available from the "Tools" drop-down menu in the Navigation bar.
View all literature mentionsSoftware for analyzing sedimentation equilibrium (SE) data from analytical ultracentrifugation experiments. It uses a model-dependent simulation of data for matching data in order to determine when equilibrium has been achieved.
View all literature mentionsSoftware designed to clean-up biosensor data. It can zero and crop data, align injection times, correct for DMSO effects and fit binding curves and offrates.
View all literature mentionsThis polyclonal targets DsRed
View all literature mentionsThis monoclonal targets chaoptin
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View all literature mentionsThis monoclonal targets Bruchpilot
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis monoclonal targets DYKDDDDK Epitope Tag
View all literature mentionsThis polyclonal targets V5 tag
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets Mouse
View all literature mentionsThis polyclonal targets IgY (IgG) (H+L)
View all literature mentionsThis monoclonal targets Viral V5-TAG
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsDrosophila melanogaster with name y[1] w[*] f[1] P{w[+mW.hs]=FRT(w[hs])}9-2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR24F10-lexA}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; Df(3L)grim-A6C, PBac{w[+mC]=WHr}grim-A6C/TM3, P{w[+mC]=GAL4-twi.G}2.3, P{UAS-2xEGFP}AH2.3, Sb[1] Ser[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR47G08-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=Rpr-11-lacZ}3 from BDSC.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR87B02-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] P{y[+t7.7] w[+mC]=hs-FLPG5.PEST}attP3; PBac{y[+mDint2] w[+mC]=10xUAS(FRT.stop)myr::smGdP-HA}VK00005 P{y[+t7.7] w[+mC]=10xUAS(FRT.stop)myr::smGdP-V5-THS-10xUAS(FRT.stop)myr::smGdP-FLAG}su(Hw)attP1 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR75F06-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{y[+mDint2]=MIC}grim[MI03811]/TM3, Sb[1] Ser[1] from BDSC.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-FLP.Exel}1, y[1] w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; Df(3L)Exel6133, P{w[+mC]=XP-U}Exel6133/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=hid-EGFP.5'F-WT}3/TM3, P{w[+mC]=ActGFP}JMR2, Ser[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name Df(3L)H99, kni[ri-1] p[p]/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=hs-FLPG5.PEST.Opt}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR75F06-lexA}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; Df(3L)BSC416/TM6C, Sb[1] cu[1] from BDSC.
View all literature mentionsDiscontinued
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR9B08-GAL4}attP2/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=hsFLP}12, y[1] w[*]; P{ry[+t7.2]=Rh4-GAL4}2/CyO; TM6B, Tb[1]/TM2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR42F06-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR23G11-lexA}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR24F10-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Apoliner}5 from BDSC.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsThis monoclonal targets Bruchpilot
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-Apoliner}5 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; Df(3L)grim-A6C, PBac{w[+mC]=WHr}grim-A6C/TM3, P{w[+mC]=GAL4-twi.G}2.3, P{UAS-2xEGFP}AH2.3, Sb[1] Ser[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-FLP.Exel}1, y[1] w[1118] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; Df(3L)BSC416/TM6C, Sb[1] cu[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; Df(3L)Exel6133, P{w[+mC]=XP-U}Exel6133/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=Rpr-11-lacZ}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] P{y[+t7.7] w[+mC]=hs-FLPG5.PEST}attP3; PBac{y[+mDint2] w[+mC]=10xUAS(FRT.stop)myr::smGdP-HA}VK00005 P{y[+t7.7] w[+mC]=10xUAS(FRT.stop)myr::smGdP-V5-THS-10xUAS(FRT.stop)myr::smGdP-FLAG}su(Hw)attP1 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{y[+mDint2]=MIC}grim[MI03811]/TM3, Sb[1] Ser[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*] f[1] P{w[+mW.hs]=FRT(w[hs])}9-2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=hid-EGFP.5'F-WT}3/TM3, P{w[+mC]=ActGFP}JMR2, Ser[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name Df(3L)H99, kni[ri-1] p[p]/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=hs-FLPG5.PEST.Opt}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR87B02-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR47G08-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR75F06-lexA}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR24F10-lexA}attP40 from BDSC.
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets Mouse
View all literature mentionsThis polyclonal targets IgY (IgG) (H+L)
View all literature mentionsThis monoclonal targets HA-Tag
View all literature mentionsThis monoclonal targets chaoptin
View all literature mentionsThis polyclonal targets DsRed
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=hsFLP}12, y[1] w[*]; P{ry[+t7.2]=Rh4-GAL4}2/CyO; TM6B, Tb[1]/TM2 from BDSC.
View all literature mentionsDiscontinued
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR42F06-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR9B08-GAL4}attP2/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR23G11-lexA}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR75F06-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR24F10-GAL4}attP2 from BDSC.
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets Viral V5-TAG
View all literature mentionsThis monoclonal targets Nectin 1
View all literature mentionsThis polyclonal targets V5 tag
View all literature mentionsThis monoclonal targets DYKDDDDK Epitope Tag
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