Searching across hundreds of databases
Sensory navigation results from coordinated transitions between distinct behavioral programs. During chemotaxis in the Drosophila melanogaster larva, the detection of positive odor gradients extends runs while negative gradients promote stops and turns. This algorithm represents a foundation for the control of sensory navigation across phyla. In the present work, we identified an olfactory descending neuron, PDM-DN, which plays a pivotal role in the organization of stops and turns in response to the detection of graded changes in odor concentrations. Artificial activation of this descending neuron induces deterministic stops followed by the initiation of turning maneuvers through head casts. Using electron microscopy, we reconstructed the main pathway that connects the PDM-DN neuron to the peripheral olfactory system and to the pre-motor circuit responsible for the actuation of forward peristalsis. Our results set the stage for a detailed mechanistic analysis of the sensorimotor conversion of graded olfactory inputs into action selection to perform goal-oriented navigation.
Pubmed ID: 30465650 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
A toolkit designed to navigate, share and collaboratively annotate massive image data sets of biological specimens. The interface enables synchronized navigation through multiple registered datasets even at vastly different scales such as in comparisons between optical and electron microscopy. The interface is inspired by GoogleMaps, with which it shares basic navigation concepts, enhanced to allow the exploration of 3D biological image data acquired by optical or physical sectioning microscopy techniques. The interface enables seamless sharing of regions of interest through bookmarks and synchronized navigation through multiple registered data sets. With massive biological image data sets it is unrealistic to create a sustainable centralized repository. A unique feature of CATMAID is its partially decentralized architecture where the presented image data can reside on any Internet accessible server and yet can be easily cross-referenced in the central database. In this way no image data are duplicated and the data producers retain full control over their images. CATMAID is intended to serve as data sharing platform for biologists using high-resolution imaging techniques to probe large specimens. Any high-throughput, high-content imaging project such as gene expression pattern screens would benefit from the interface for data sharing and annotation. Features: * Fast terabyte-scale image data browsing * Collaborative microcircuit reconstruction and annotation * Flexible hierarchical semantic annotation * Multiple linked image stack display * Neuron Catalog * SVG and WebGL-based neuronal morphology viewer * Open source software
View all literature mentionsCommercial vendor and service provider of laboratory reagents and antibodies. Supplier of scientific instrumentation, reagents and consumables, and software services.
View all literature mentionsAmerican chemical, life science and biotechnology company owned by Merck KGaA. Merger of Sigma Chemical Company and Aldrich Chemical Company. Provides organic and inorganic chemicals, building blocks, reagents, advanced materials and stable isotopes for chemical synthesis, medicinal chemistry and materials science, antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, proteins, peptides, amino acids and their derivatives.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=R75C02-GAL4.DBD}attP2 from BDSC.
View all literature mentionsThis monoclonal targets HA-Tag
View all literature mentionsThis monoclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis monoclonal targets Bruchpilot
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis monoclonal targets choline acetyltransferase
View all literature mentionsThis polyclonal targets Drosophila vesicular glutamate transporter (CG9887), amino acids 2-87
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis unknown targets Mouse IgA, alpha chain specific
View all literature mentionsDrosophila melanogaster with name w[1118] P{y[+t7.7] w[+mC]=R57C10-FLPL}su(Hw)attP8; PBac{y[+mDint2] w[+mC]=10xUAS(FRT.stop)myr::smGdP-HA}VK00005 P{y[+t7.7] w[+mC]=10xUAS(FRT.stop)myr::smGdP-V5-THS-10xUAS(FRT.stop)myr::smGdP-FLAG}su(Hw)attP1 from BDSC.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-TeTxLC.tnt}G2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] P{y[+t7.7] w[+mC]=20XUAS-IVS-CsChrimson.mVenus}attP18 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-IVS-CsChrimson.mVenus}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=VT002081-GAL4.DBD}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR75C02-GAL4}attP2 from BDSC.
View all literature mentionsA development environment for engineers and scientists to visualize, create, and code engineering systems. The system design software is integrated with all measurement hardware and contains signal processing IP. Other features include multithreaded execution, software deployment to hardware, and program integration into a single environment.
View all literature mentionsMulti paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=R23E07-p65.AD}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR75C02-lexA}attP40/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{GD3054}v40918 from Flybase.
View all literature mentionsA development environment for engineers and scientists to visualize, create, and code engineering systems. The system design software is integrated with all measurement hardware and contains signal processing IP. Other features include multithreaded execution, software deployment to hardware, and program integration into a single environment.
View all literature mentionsA development environment for engineers and scientists to visualize, create, and code engineering systems. The system design software is integrated with all measurement hardware and contains signal processing IP. Other features include multithreaded execution, software deployment to hardware, and program integration into a single environment.
View all literature mentionsA development environment for engineers and scientists to visualize, create, and code engineering systems. The system design software is integrated with all measurement hardware and contains signal processing IP. Other features include multithreaded execution, software deployment to hardware, and program integration into a single environment.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=VT002081-GAL4.DBD}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=R23E07-p65.AD}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] P{y[+t7.7] w[+mC]=R57C10-FLPL}su(Hw)attP8; PBac{y[+mDint2] w[+mC]=10xUAS(FRT.stop)myr::smGdP-HA}VK00005 P{y[+t7.7] w[+mC]=10xUAS(FRT.stop)myr::smGdP-V5-THS-10xUAS(FRT.stop)myr::smGdP-FLAG}su(Hw)attP1 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] P{y[+t7.7] w[+mC]=20XUAS-IVS-CsChrimson.mVenus}attP18 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-IVS-CsChrimson.mVenus}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-TeTxLC.tnt}G2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR75C02-lexA}attP40/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{GD3054}v40918 from Flybase.
View all literature mentionsThis monoclonal targets Bruchpilot
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR75C02-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{GD3054}v40918 from Flybase.
View all literature mentionsThis monoclonal targets Bruchpilot
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis monoclonal targets HA-Tag
View all literature mentionsThis monoclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis monoclonal targets choline acetyltransferase
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=VT002081-GAL4.DBD}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-IVS-CsChrimson.mVenus}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] P{y[+t7.7] w[+mC]=R57C10-FLPL}su(Hw)attP8; PBac{y[+mDint2] w[+mC]=10xUAS(FRT.stop)myr::smGdP-HA}VK00005 P{y[+t7.7] w[+mC]=10xUAS(FRT.stop)myr::smGdP-V5-THS-10xUAS(FRT.stop)myr::smGdP-FLAG}su(Hw)attP1 from BDSC.
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets Drosophila vesicular glutamate transporter (CG9887), amino acids 2-87
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=R23E07-p65.AD}attP40 from BDSC.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsMulti paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsThis unknown targets Mouse IgA, alpha chain specific
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis monoclonal targets HA-Tag
View all literature mentionsThis polyclonal targets Drosophila vesicular glutamate transporter (CG9887), amino acids 2-87
View all literature mentionsThis monoclonal targets choline acetyltransferase
View all literature mentionsThis monoclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis monoclonal targets Bruchpilot
View all literature mentionsDrosophila melanogaster with name w[1118]; P{GD3054}v40918 from Flybase.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR75C02-lexA}attP40/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR75C02-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] P{y[+t7.7] w[+mC]=20XUAS-IVS-CsChrimson.mVenus}attP18 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-TeTxLC.tnt}G2 from BDSC.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis monoclonal targets HA-Tag
View all literature mentionsThis polyclonal targets Drosophila vesicular glutamate transporter (CG9887), amino acids 2-87
View all literature mentionsThis monoclonal targets choline acetyltransferase
View all literature mentionsThis monoclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsMulti paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsMulti paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsThis unknown targets Mouse IgA, alpha chain specific
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgA, alpha chain specific
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=R23E07-p65.AD}attP40 from BDSC.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
