Searching across hundreds of databases
Proper control of the mitochondrial Ca2+ uniporter's pore (MCU) is required to allow Ca2+-dependent activation of oxidative metabolism and to avoid mitochondrial Ca2+ overload and cell death. The MCU's gatekeeping and cooperative activation is mediated by the Ca2+-sensing MICU1 protein, which has been proposed to form dimeric complexes anchored to the EMRE scaffold of MCU. We unexpectedly find that MICU1 suppresses inhibition of MCU by ruthenium red/Ru360, which bind to MCU's DIME motif, the selectivity filter. This led us to recognize in MICU1's sequence a putative DIME interacting domain (DID), which is required for both gatekeeping and cooperative activation of MCU and for cell survival. Thus, we propose that MICU1 has to interact with the D-ring formed by the DIME domains in MCU to control the uniporter.
Pubmed ID: 30454562 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This unknown targets HA Tag
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis monoclonal targets mtHSP70
View all literature mentionsThis polyclonal targets Human Prohibitin - Mitochondrial Marker
View all literature mentionsThis polyclonal targets CBARA1 antibody produced in rabbit
View all literature mentionsThis polyclonal targets EFHA1 antibody
View all literature mentionsThis polyclonal targets CCDC109A
View all literature mentionsStatistical analysis and scientific graphing software for Windows OS.
View all literature mentionsStatistical analysis and scientific graphing software for Windows OS.
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis unknown targets HA Tag
View all literature mentionsThis polyclonal targets Human Prohibitin - Mitochondrial Marker
View all literature mentionsThis monoclonal targets mtHSP70
View all literature mentionsThis polyclonal targets EFHA1 antibody
View all literature mentionsThis polyclonal targets CCDC109A
View all literature mentionsThis polyclonal targets CBARA1 antibody produced in rabbit
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
