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Approximately half of human genes generate mRNAs with alternative 3' untranslated regions (3'UTRs). Through 3'UTR-mediated protein-protein interactions, alternative 3'UTRs enable multi-functionality of proteins with identical amino acid sequence. While studying how information on protein features is transferred from 3'UTRs to proteins, we discovered that the broadly expressed RNA-binding protein TIS11B forms a membraneless organelle, called TIS granule, that enriches membrane protein-encoding mRNAs with multiple AU-rich elements. TIS granules form a reticular meshwork intertwined with the endoplasmic reticulum (ER). The association between TIS granules and the ER creates a subcellular compartment-the TIGER domain-with a biophysically and biochemically distinct environment from the cytoplasm. This compartment promotes 3'UTR-mediated interaction of SET with membrane proteins, thus allowing increased surface expression and functional diversity of proteins, including CD47 and PD-L1. The TIGER domain is a subcellular compartment that enables formation of specific and functionally relevant protein-protein interactions that cannot be established outside.
Pubmed ID: 30449617 RIS Download
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Imaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsA commercial organization which provides assay technologies to isolate DNA, RNA, and proteins from any biological sample. Assay technologies are then used to make specific target biomolecules, such as the DNA of a specific virus, visible for subsequent analysis.
View all literature mentionsA data analysis software developed to simplify and record data from fluorescent related assays such as Western Blots, EMSAs, and Western Assays. This software will consolidate all of the resulting data into one easy-to-track image, and thus removes the need for multiple exposures, as well as standardizing the resulting fluorescent bands without image saturation, blowout, or removed sensitivity. Odyssey CLx is capable of scanning multiple mini-blots, microplates, or slides at the same time.
View all literature mentionsSoftware application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.
View all literature mentionsThis monoclonal targets SET
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View all literature mentionsThis monoclonal targets ELAVL1, ELAVL2, ELAVL3, ELAVL4
View all literature mentionsThis monoclonal targets hnRNP-Q
View all literature mentionsThis monoclonal targets mCherry antibody [1C51]
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Human FXR1
View all literature mentionsThis unknown targets Chicken IgG (H&L)
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis monoclonal targets Actin
View all literature mentionsThis monoclonal targets CD47 antibody [EPR4150(2)]
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis monoclonal targets α-Tubulin
View all literature mentionsThis monoclonal targets FUS
View all literature mentionsThis polyclonal secondary targets IgY (H+L)
View all literature mentionsThis monoclonal targets hnRNP A1 (D-4)
View all literature mentionsThis polyclonal targets ZFP36L1/2
View all literature mentionsThis polyclonal targets KHSRP
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal targets FUBP3 (center) antibody produced in rabbit
View all literature mentionsCell line NIH 3T3 is a Spontaneously immortalized cell line with a species of origin Mus musculus
View all literature mentionsCell line Caov-3 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line MCF-7 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line MCF-7 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsCell line NIH 3T3 is a Spontaneously immortalized cell line with a species of origin Mus musculus
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis unknown targets Chicken IgG (H&L)
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis unknown targets Mouse IgG (H&L)
View all literature mentionsThis polyclonal secondary targets IgY (H+L)
View all literature mentionsThis monoclonal targets FUS
View all literature mentionsThis monoclonal targets hnRNP-Q
View all literature mentionsThis polyclonal targets FUBP3 (center) antibody produced in rabbit
View all literature mentionsThis polyclonal targets ZFP36L1/2
View all literature mentionsThis monoclonal targets CD47 antibody [EPR4150(2)]
View all literature mentionsThis monoclonal targets hnRNP A1 (D-4)
View all literature mentionsThis monoclonal targets mCherry antibody [1C51]
View all literature mentionsThis monoclonal targets SET
View all literature mentionsCell line Caov-3 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis monoclonal targets α-Tubulin
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets KHSRP
View all literature mentionsThis monoclonal targets ELAVL1, ELAVL2, ELAVL3, ELAVL4
View all literature mentionsThis monoclonal targets Actin
View all literature mentionsThis unknown targets Human FXR1
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