Innate immune memory is an emerging area of research. However, innate immune memory at major mucosal sites remains poorly understood. Here, we show that respiratory viral infection induces long-lasting memory alveolar macrophages (AMs). Memory AMs are programed to express high MHC II, a defense-ready gene signature, and increased glycolytic metabolism, and produce, upon re-stimulation, neutrophil chemokines. Using a multitude of approaches, we reveal that the priming, but not maintenance, of memory AMs requires the help from effector CD8 T cells. T cells jump-start this process via IFN-γ production. We further find that formation and maintenance of memory AMs are independent of monocytes or bone marrow progenitors. Finally, we demonstrate that memory AMs are poised for robust trained immunity against bacterial infection in the lung via rapid induction of chemokines and neutrophilia. Our study thus establishes a new paradigm of immunological memory formation whereby adaptive T-lymphocytes render innate memory of mucosal-associated macrophages.
Pubmed ID: 30433869 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This monoclonal targets Mouse CD86
View all literature mentionsThis monoclonal targets CD64
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets CD24 (Heat Stable Antigen)
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets Mouse CD45R
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets Mouse CD45.1
View all literature mentionsThis monoclonal targets CD16/CD32
View all literature mentionsThis monoclonal targets CD192
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD3 Molecular Complex
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets Mouse CD80
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets Siglec-F
View all literature mentionsThis monoclonal targets CD284
View all literature mentionsMus musculus with name B6.129S7-Ifngr1tm1Agt/J from IMSR.
View all literature mentionsMus musculus with name CByJ.SJL(B6)-Ptprca/J from IMSR.
View all literature mentionsMus musculus with name B6.129S7-Ifngtm1Ts/J from IMSR.
View all literature mentionsMus musculus with name BALB/cAnNCrl from IMSR.
View all literature mentionsMus musculus with name BALB/cJ from IMSR.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsMus musculus with name B6.SJL-Ptprca Pepc/BoyJ from IMSR.
View all literature mentionsMus musculus with name B6.129S7-Rag1tm1Mom/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsA software package for performing 2D microscope image processing and integrating and controlling a diverse array of instrumentation in a laboratory environment. The software suite has four basic areas of operation acquisition, image presentation, and storage, analysis, and automation.
View all literature mentionsMus musculus with name B6.129S4-Ccr2tm1Ifc/J from IMSR.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsMus musculus with name CBySmn.Cg-Prkdcscid/J from IMSR.
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD24 (Heat Stable Antigen)
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsA software package for performing 2D microscope image processing and integrating and controlling a diverse array of instrumentation in a laboratory environment. The software suite has four basic areas of operation acquisition, image presentation, and storage, analysis, and automation.
View all literature mentionsMus musculus with name B6.SJL-Ptprca Pepc/BoyJ from IMSR.
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsMus musculus with name B6.129S7-Ifngr1tm1Agt/J from IMSR.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsMus musculus with name CByJ.SJL(B6)-Ptprca/J from IMSR.
View all literature mentionsMus musculus with name CBySmn.Cg-Prkdcscid/J from IMSR.
View all literature mentionsMus musculus with name B6.129S7-Rag1tm1Mom/J from IMSR.
View all literature mentionsMus musculus with name B6.129S7-Ifngtm1Ts/J from IMSR.
View all literature mentionsMus musculus with name B6.129S4-Ccr2tm1Ifc/J from IMSR.
View all literature mentionsThis monoclonal targets CD16/CD32
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis monoclonal targets Mouse CD45.1
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsMus musculus with name BALB/cAnNCrl from IMSR.
View all literature mentionsMus musculus with name BALB/cJ from IMSR.
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD192
View all literature mentionsThis monoclonal targets CD284
View all literature mentionsThis monoclonal targets Mouse CD80
View all literature mentionsThis monoclonal targets Mouse CD86
View all literature mentionsThis monoclonal targets CD3 Molecular Complex
View all literature mentionsThis monoclonal targets MHC Class II (I-A/I-E)
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets Siglec-F
View all literature mentionsThis monoclonal targets CD64
View all literature mentionsThis monoclonal targets Mouse CD45R
View all literature mentions