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Natural killer (NK) cells are innate lymphoid cells (ILCs) involved in antimicrobial and antitumoral responses. Several NK cell subsets have been reported in humans and mice, but their heterogeneity across organs and species remains poorly characterized. We assessed the diversity of human and mouse NK cells by single-cell RNA sequencing on thousands of individual cells isolated from spleen and blood. Unbiased transcriptional clustering revealed two distinct signatures differentiating between splenic and blood NK cells. This analysis at single-cell resolution identified three subpopulations in mouse spleen and four in human spleen, and two subsets each in mouse and human blood. A comparison of transcriptomic profiles within and between species highlighted the similarity of the two major subsets, NK1 and NK2, across organs and species. This unbiased approach provides insight into the biology of NK cells and establishes a rationale for the translation of mouse studies to human physiology and disease.
Pubmed ID: 30413361 RIS Download
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Collection of data of protein sequence and functional information. Resource for protein sequence and annotation data. Consortium for preservation of the UniProt databases: UniProt Knowledgebase (UniProtKB), UniProt Reference Clusters (UniRef), and UniProt Archive (UniParc), UniProt Proteomes. Collaboration between European Bioinformatics Institute (EMBL-EBI), SIB Swiss Institute of Bioinformatics and Protein Information Resource. Swiss-Prot is a curated subset of UniProtKB.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
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View all literature mentionsSoftware environment and programming language for statistical computing and graphics. R is integrated suite of software facilities for data manipulation, calculation and graphical display. Can be extended via packages. Some packages are supplied with the R distribution and more are available through CRAN family.It compiles and runs on wide variety of UNIX platforms, Windows and MacOS.
View all literature mentionsOpen source and enterprise ready professional software for R statistical computing environment. Integrated development environment for R. Includes console, syntax highlighting editor that supports direct code execution, as well as tools for plotting, history, debugging and workspace management. Available in open source and commercial editions and runs on desktop Windows, Mac, and Linux or in browser connected to RStudio Server or RStudio Server Pro (Debian/Ubuntu, RedHat/CentOS, and SUSE Linux).
View all literature mentionsSoftware as R package designed for QC, analysis, and exploration of single cell RNA-seq data. Enable users to identify and interpret sources of heterogeneity from single cell transcriptomic measurements, and to integrate diverse types of single cell data.
View all literature mentionsThis monoclonal targets CD335 (NKp46)
View all literature mentionsThis monoclonal targets CD335 (NKp46)
View all literature mentionsOpen source and enterprise ready professional software for R statistical computing environment. Integrated development environment for R. Includes console, syntax highlighting editor that supports direct code execution, as well as tools for plotting, history, debugging and workspace management. Available in open source and commercial editions and runs on desktop Windows, Mac, and Linux or in browser connected to RStudio Server or RStudio Server Pro (Debian/Ubuntu, RedHat/CentOS, and SUSE Linux).
View all literature mentionsThis monoclonal targets CD16 (FcγRIII)
View all literature mentionsSoftware as R package designed for QC, analysis, and exploration of single cell RNA-seq data. Enable users to identify and interpret sources of heterogeneity from single cell transcriptomic measurements, and to integrate diverse types of single cell data.
View all literature mentionsSoftware environment and programming language for statistical computing and graphics. R is integrated suite of software facilities for data manipulation, calculation and graphical display. Can be extended via packages. Some packages are supplied with the R distribution and more are available through CRAN family.It compiles and runs on wide variety of UNIX platforms, Windows and MacOS.
View all literature mentionsThis monoclonal targets Human CD127
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD107a (LAMP-1)
View all literature mentionsThis monoclonal targets CD161
View all literature mentionsThis monoclonal targets CD56/NCAM1
View all literature mentionsThis monoclonal targets CX3CR1
View all literature mentionsThis monoclonal targets Human CD14 (LPS receptor) FITC Clone RMO52
View all literature mentionsThis monoclonal targets CD28
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets IFN-γ
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis monoclonal targets CD16 / CD32
View all literature mentionsThis monoclonal targets Mouse CCR2 Phycoerythrin MAb (Clone 475301)
View all literature mentionsThis monoclonal targets CD335 (NKp46)
View all literature mentionsThis monoclonal targets NK1.1
View all literature mentionsThis monoclonal targets CD335 (NKp46)
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD335
View all literature mentionsThis monoclonal targets CD11a CD18
View all literature mentionsThis monoclonal targets CD90.2
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD27
View all literature mentionsThis monoclonal targets CD45
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