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Macrophages (MØs) expressing the endocytic sialic acid-binding immunoglobulin-like lectin 1 (siglec-1, CD169, sialoadhesin) are known to be adept at antigen capture-primarily due to their strategic location within lymphatic tissues. Antigen concentrated in these cells can be harnessed to induce potent anti-tumor/anti-pathogen cytotoxic (CD8+) T cell responses. Here, we describe a chemical platform that exploits the CD169-mediated antigen capture pathway for biased priming of antigen-specific CD4+ or CD8+ T cells in vivo. In the absence of a toll-like receptor (TLR) agonist, antigen delivery through CD169 produced robust CD4+ T cell priming only. However, simultaneous treatment with targeted antigen and a TLR7 agonist induced CD8+ T cell priming, with concomitant suppression of the CD4+ T cell response. We exploited these observations to manipulate the activation ratio of CD4+/CD8+ T cells in the same animal. These findings represent a unique chemical strategy for targeting CD169+ macrophages to modulate antigen-specific T cell immunity.
Pubmed ID: 30393066 RIS Download
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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 18,2023. Platform that delivers software tools to capture, process, measure, analyze and share images and data for scientific and industrial imaging community. Used for image-based data collection and analysis to increase accuracy and automate research, development, and quality processes.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 18,2023. Platform that delivers software tools to capture, process, measure, analyze and share images and data for scientific and industrial imaging community. Used for image-based data collection and analysis to increase accuracy and automate research, development, and quality processes.
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