The activator and composition of the NLRP6 inflammasome remain poorly understood. We find that lipoteichoic acid (LTA), a molecule produced by Gram-positive bacteria, binds and activates NLRP6. In response to cytosolic LTA or infection with Listeria monocytogenes, NLRP6 recruited caspase-11 and caspase-1 via the adaptor ASC. NLRP6 activation by LTA induced processing of caspase-11, which promoted caspase-1 activation and interleukin-1β (IL-1β)/IL-18 maturation in macrophages. Nlrp6-/- and Casp11-/- mice were less susceptible to L. monocytogenes infection, which was associated with reduced pathogen loads and impaired IL-18 production. Administration of IL-18 to Nlrp6-/- or Casp11-/- mice restored the susceptibility of mutant mice to L. monocytogenes infection. These results reveal a previously unrecognized innate immunity pathway triggered by cytosolic LTA that is sensed by NLRP6 and exacerbates systemic Gram-positive pathogen infection via the production of IL-18.
Pubmed ID: 30392956 RIS Download
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This monoclonal targets Caspase 11 antibody produced in rat
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View all literature mentionsThis unknown targets ASC
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View all literature mentionsThis monoclonal targets Lipoteichic Acid Lipoteichic Acid
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View all literature mentionsThis polyclonal secondary targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG, F'2 Fragment Specific
View all literature mentionsThis monoclonal targets Glyceraldehyde-3-PDH (GAPDH)
View all literature mentionsThis monoclonal targets HA
View all literature mentionsThis polyclonal targets IgG (H+L)
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View all literature mentionsThis unknown targets Asc
View all literature mentionsThis polyclonal targets caspase-1 p10
View all literature mentionsThis polyclonal targets NLRP6
View all literature mentionsThis unknown targets S•Tag™
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets ASC
View all literature mentionsThis unknown targets Mouse IgG, F'2 Fragment Specific
View all literature mentionsThis polyclonal secondary targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets Mouse IL-1 beta / IL-1F2
View all literature mentionsThis monoclonal targets HA
View all literature mentionsThis unknown targets Asc
View all literature mentionsThis unknown targets S•Tag™
View all literature mentionsThis monoclonal targets Glyceraldehyde-3-PDH (GAPDH)
View all literature mentionsThis polyclonal targets caspase-1 p10
View all literature mentionsThis monoclonal targets LPS core
View all literature mentionsThis polyclonal targets NLRP6
View all literature mentionsThis monoclonal targets Lipoteichic Acid Lipoteichic Acid
View all literature mentionsThis monoclonal targets FLAG
View all literature mentionsThis unknown targets Human GSDMD, aa 126-138
View all literature mentionsThis monoclonal targets Caspase 11 antibody produced in rat
View all literature mentions