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Publication

Hair follicle epidermal stem cells define a niche for tactile sensation.

eLife | 2018

The heterogeneity and compartmentalization of stem cells is a common principle in many epithelia, and is known to function in epithelial maintenance, but its other physiological roles remain elusive. Here we show transcriptional and anatomical contributions of compartmentalized epidermal stem cells in tactile sensory unit formation in the mouse hair follicle. Epidermal stem cells in the follicle upper-bulge, where mechanosensory lanceolate complexes innervate, express a unique set of extracellular matrix (ECM) and neurogenesis-related genes. These epidermal stem cells deposit an ECM protein called EGFL6 into the collar matrix, a novel ECM that tightly ensheathes lanceolate complexes. EGFL6 is required for the proper patterning, touch responses, and αv integrin-enrichment of lanceolate complexes. By maintaining a quiescent original epidermal stem cell niche, the old bulge, epidermal stem cells provide anatomically stable follicle-lanceolate complex interfaces, irrespective of the stage of follicle regeneration cycle. Thus, compartmentalized epidermal stem cells provide a niche linking the hair follicle and the nervous system throughout the hair cycle.

Pubmed ID: 30355452 RIS Download

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Associated grants

Agency: Wellcome Trust, United Kingdom
Agency: Medical Research Council, United Kingdom
Id: G1100073
Agency: Medical Research Council, United Kingdom
Id: MR/P018823/1
Agency: Biotechnology and Biological Sciences Research Council, United Kingdom

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Imaris (tool)

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Illumina Real Time Analysis (tool)

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FastQC (tool)

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Quality control software that perform checks on raw sequence data coming from high throughput sequencing pipelines. This software also provides a modular set of analyses which can give a quick impression of the quality of the data prior to further analysis.

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