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Lasting changes in gene expression are critical for the formation of long-term memories (LTMs), depending on the conserved CrebB transcriptional activator. While requirement of distinct neurons in defined circuits for different learning and memory phases have been studied in detail, only little is known regarding the gene regulatory changes that occur within these neurons. We here use the fruit fly as powerful model system to study the neural circuits of CrebB-dependent appetitive olfactory LTM. We edited the CrebB locus to create a GFP-tagged CrebB conditional knockout allele, allowing us to generate mutant, post-mitotic neurons with high spatial and temporal precision. Investigating CrebB-dependence within the mushroom body (MB) circuit we show that MB α/β and α'/β' neurons as well as MBON α3, but not in dopaminergic neurons require CrebB for LTM. Thus, transcriptional memory traces occur in different neurons within the same neural circuit.
Pubmed ID: 30346271 RIS Download
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Imaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsAmerican chemical, life science and biotechnology company owned by Merck KGaA. Merger of Sigma Chemical Company and Aldrich Chemical Company. Provides organic and inorganic chemicals, building blocks, reagents, advanced materials and stable isotopes for chemical synthesis, medicinal chemistry and materials science, antibiotics, buffers, carbohydrates, enzymes, forensic tools, hematology and histology, nucleotides, proteins, peptides, amino acids and their derivatives.
View all literature mentionsA commercial antibody supplier which supplies primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mC]=UAS-FLP.D}JD1 from BDSC.
View all literature mentionsDrosophila melanogaster with name Canton-S from BDSC.
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets Tyrosine Hydroxylase
View all literature mentionsThis monoclonal targets Repo; Reversed polarity protein
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis monoclonal targets Discs large (Drosophila)
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-FLPD5.PEST}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-FLPG5.PEST}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] M{w[+mC]=nos-Cas9.P}ZH-2A w[*] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR58E02-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=GAL4-5-HTR1B.Y}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mGT]=GT1}BG01228[BG01228] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=tubP-GAL80[ts]}20; TM2/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mW.hs]=GawB}Cka[c305a] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+m*]=nSyb-GAL4.S}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[67c23]; P{w[+mW.hs]=GawB}Hr39[c739] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mW.hs]=GawB}OK107 ey[OK107] from DGGR.
View all literature mentionsThis monoclonal targets Repo; Reversed polarity protein
View all literature mentionsThis monoclonal targets Discs large (Drosophila)
View all literature mentionsThis polyclonal targets Tyrosine Hydroxylase
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-FLPG5.PEST}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] M{w[+mC]=nos-Cas9.P}ZH-2A w[*] from BDSC.
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=tubP-GAL80[ts]}20; TM2/TM6B, Tb[1] from BDSC.
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mGT]=GT1}BG01228[BG01228] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-FLPD5.PEST}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR58E02-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=GAL4-5-HTR1B.Y}2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mW.hs]=GawB}Cka[c305a] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=GMR58E02-GAL4}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mW.hs]=GawB}Cka[c305a] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mGT]=GT1}BG01228[BG01228] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=GAL4-5-HTR1B.Y}2 from BDSC.
View all literature mentionsThis monoclonal targets Repo; Reversed polarity protein
View all literature mentionsDrosophila melanogaster with name y[1] M{w[+mC]=nos-Cas9.P}ZH-2A w[*] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-FLPD5.PEST}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=tubP-GAL80[ts]}20; TM2/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=20XUAS-FLPG5.PEST}attP40 from BDSC.
View all literature mentionsThis monoclonal targets Discs large (Drosophila)
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis polyclonal targets Tyrosine Hydroxylase
View all literature mentionsThis polyclonal targets GFP
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