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Increased activation of the renin-angiotensin-aldosterone system (RAAS) and elevated growth factor production are of crucial importance in the development of renal fibrosis leading to diabetic kidney disease. The aim of this study was to provide evidence for the antifibrotic potential of RAAS inhibitor (RAASi) treatment and to explore the exact mechanism of this protective effect. We found that RAASi ameliorate diabetes-induced renal interstitial fibrosis and decrease profibrotic growth factor production. RAASi prevents fibrosis by acting directly on proximal tubular cells, and inhibits hyperglycaemia-induced growth factor production and thereby fibroblast activation. These results suggest a novel therapeutic indication and potential of RAASi in the treatment of renal fibrosis.
Pubmed ID: 30324679 RIS Download
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Software tool as a digital virtual microscope for viewing and moving scanned histological slides and for making annotations and measurements on them. Used in digital pathology. Helps to simplify the areas of the pathology workflow where imaging, slide digitization, storage, archivation, visualization and analysis are performed.
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View all literature mentionsThis unknown targets Hoechst 33342
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
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View all literature mentionsSoftware tool as a digital virtual microscope for viewing and moving scanned histological slides and for making annotations and measurements on them. Used in digital pathology. Helps to simplify the areas of the pathology workflow where imaging, slide digitization, storage, archivation, visualization and analysis are performed.
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View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. Commercial software vendor.
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View all literature mentionsCell line HK-2 [Human kidney] is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line NRK-49F is a Spontaneously immortalized cell line with a species of origin Rattus norvegicus
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View all literature mentionsSoftware used for Bio-Rad imaging systems to acquire, quantitate, and analyze a variety of data. The software allows automatic configuration of imaging systems with appropriate filters, lasers, LEDs, and other illumination sources. It also contains tools for automated analysis of tests and assays such as 1-D electrophoretic gels, western blots, and colony counts.
View all literature mentionsSoftware used for Bio-Rad imaging systems to acquire, quantitate, and analyze a variety of data. The software allows automatic configuration of imaging systems with appropriate filters, lasers, LEDs, and other illumination sources. It also contains tools for automated analysis of tests and assays such as 1-D electrophoretic gels, western blots, and colony counts.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware tool as a digital virtual microscope for viewing and moving scanned histological slides and for making annotations and measurements on them. Used in digital pathology. Helps to simplify the areas of the pathology workflow where imaging, slide digitization, storage, archivation, visualization and analysis are performed.
View all literature mentionsRattus norvegicus with name WI from RGD.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsCell line NRK-49F is a Spontaneously immortalized cell line with a species of origin Rattus norvegicus
View all literature mentionsThis polyclonal targets PDGFRB
View all literature mentionsCell line HK-2 [Human kidney] is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis monoclonal targets Actin, α-Smooth Muscle
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. Commercial software vendor.
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsLight cycler software for analysis of quatitative real time PCR
View all literature mentionsThis unknown targets Hoechst 33342
View all literature mentionsSoftware used to compile images obtained from the Zeiss LSM 510 confocal microscope. The browser can be used for general image archiving and handling and interactive measurement in labs and workgroups. Features include orthogonal sectioning, 3D cut function, 3D view with calculation of single projections, and interactive measurement functions in the overlay dialog, such as scale bar, distance, and area.
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware for advanced primer design. Can be used for some advanced primer functions, such as adjusting mispriming parameters and creating a primer catalog. Suitable for determining the best primer pairs or probes for PCR, sequencing, and hybridization experiments.
View all literature mentionsSoftware for advanced primer design. Can be used for some advanced primer functions, such as adjusting mispriming parameters and creating a primer catalog. Suitable for determining the best primer pairs or probes for PCR, sequencing, and hybridization experiments.
View all literature mentionsLight cycler software for analysis of quatitative real time PCR
View all literature mentionsSoftware used to compile images obtained from the Zeiss LSM 510 confocal microscope. The browser can be used for general image archiving and handling and interactive measurement in labs and workgroups. Features include orthogonal sectioning, 3D cut function, 3D view with calculation of single projections, and interactive measurement functions in the overlay dialog, such as scale bar, distance, and area.
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis unknown targets
View all literature mentionsThis unknown targets Hoechst 33342
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets PDGFRB
View all literature mentionsThis monoclonal targets Actin, α-Smooth Muscle
View all literature mentionsCell line NRK-49F is a Spontaneously immortalized cell line with a species of origin Rattus norvegicus
View all literature mentionsCell line HK-2 [Human kidney] is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsSoftware tool as a digital virtual microscope for viewing and moving scanned histological slides and for making annotations and measurements on them. Used in digital pathology. Helps to simplify the areas of the pathology workflow where imaging, slide digitization, storage, archivation, visualization and analysis are performed.
View all literature mentionsRattus norvegicus with name WI from RGD.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE, documented on July 17, 2013. Commercial software vendor.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
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