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Publication

Leukemia inhibitory factor modulates the peripheral immune response in a rat model of emergent large vessel occlusion.

Journal of neuroinflammation | 2018

The migration of peripheral immune cells and splenocytes to the ischemic brain is one of the major causes of delayed neuroinflammation after permanent large vessel stroke. Other groups have demonstrated that leukemia inhibitory factor (LIF), a cytokine that promotes neural cell survival through upregulation of antioxidant enzymes, promotes an anti-inflammatory phenotype in several types of immune cells. The goal of this study was to determine whether LIF treatment modulates the peripheral immune response after stroke.

Pubmed ID: 30322390 RIS Download

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Associated grants

Agency: NINDS NIH HHS, United States
Id: R21 NS078517
Agency: NINDS NIH HHS, United States
Id: R01 NS091146
Agency: NINDS NIH HHS, United States
Id: R56 NS091146
Agency: NINDS NIH HHS, United States
Id: R01 NS091582

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THIS RESOURCE IS NO LONGER IN SERVICE, documented on February 1st, 2022. Software application for genetic analysis of classical biometric traits like blood pressure or height that are caused by a combination of polygenic inheritance and complex environmental forces. (entry from Genetic Analysis Software)

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