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Each taste modality is generally encoded by a single, molecularly defined, population of sensory cells. However, salt stimulates multiple taste pathways in mammals and insects, suggesting a more complex code for salt taste. Here, we examine salt coding in Drosophila. After creating a comprehensive molecular map comprised of five discrete sensory neuron classes across the fly labellum, we find that four are activated by salt: two exhibiting characteristics of 'low salt' cells, and two 'high salt' classes. Behaviorally, low salt attraction depends primarily on 'sweet' neurons, with additional input from neurons expressing the ionotropic receptor IR94e. High salt avoidance is mediated by 'bitter' neurons and a population of glutamatergic neurons expressing Ppk23. Interestingly, the impact of these glutamatergic neurons depends on prior salt consumption. These results support a complex model for salt coding in flies that combinatorially integrates inputs from across cell types to afford robust and flexible salt behaviors.
Pubmed ID: 30307393 RIS Download
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View all literature mentionsDrosophila melanogaster with name w[*]; Mi{Trojan-GAL4.0}ChAT[MI04508-TG4.0] CG7715[MI04508-TG4.0-X]/TM6B, Tb[1] from BDSC.
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View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{Trojan-3XGAL80.2}VGlut[MI04979-T3XG80.2] from BDSC.
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View all literature mentionsDrosophila melanogaster with name w[*]; Mi{Trojan-GAL4.2}VGlut[MI04979-TG4.2]/CyO from BDSC.
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View all literature mentionsDrosophila melanogaster with name w[*]; Mi{Trojan-lexA:QFAD.2}VGlut[MI04979-TlexA:QFAD.2]/CyO, P{Dfd-GMR-nvYFP}2 from BDSC.
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