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Chimeric antigen receptor anti-CD19 (CAR19)-T cell immunotherapy-induced clinical remissions in CD19+ B cell lymphomas are often short lived. We tested whether CAR19-engineering of the CD1d-restricted invariant natural killer T (iNKT) cells would result in enhanced anti-lymphoma activity. CAR19-iNKT cells co-operatively activated by CD1d- and CAR19-CD19-dependent interactions are more effective than CAR19-T cells against CD1d-expressing lymphomas in vitro and in vivo. The swifter in vivo anti-lymphoma activity of CAR19-iNKT cells and their enhanced ability to eradicate brain lymphomas underpinned an improved tumor-free and overall survival. CD1D transcriptional de-repression by all-trans retinoic acid results in further enhanced cytotoxicity of CAR19-iNKT cells against CD19+ chronic lymphocytic leukemia cells. Thus, iNKT cells are a highly efficient platform for CAR-based immunotherapy of lymphomas and possibly other CD1d-expressing cancers.
Pubmed ID: 30300581 RIS Download
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Software tool for fast and high throughput alignment of shotgun cDNA sequencing reads generated by transcriptomics technologies. Fast splice junction mapper for RNA-Seq reads. Aligns RNA-Seq reads to mammalian-sized genomes using ultra high-throughput short read aligner Bowtie, and then analyzes mapping results to identify splice junctions between exons.TopHat2 is accurate alignment of transcriptomes in presence of insertions, deletions and gene fusions.
View all literature mentionsIn vivo imaging software which facilitates workflow for in vivo optical, X-ray and microCT image acquisition, analysis and data organization.
View all literature mentionsSoftware tool for transcriptome assembly and differential expression analysis for RNA-Seq. Includes script called cuffmerge that can be used to merge together several Cufflinks assemblies. It also handles running Cuffcompare as well as automatically filtering a number of transfrags that are likely to be artifacts. If the researcher has a reference GTF file, the researcher can provide it to the script to more effectively merge novel isoforms and maximize overall assembly quality.
View all literature mentionsSoftware performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
View all literature mentionsA collection of tools for flow cytometer and application setup, data acquisition, and data analysis that help streamline flow cytometry workflows. It provides features to help users integrate flow systems into new application areas, including index sorting for stem cell and single-cell applications, as well as automation protocols for high-throughput and robotic laboratories.
View all literature mentionsA next-generation web-based application that aims to provide an integrated solution for both visualization and analysis of deep-sequencing data, along with simple access to public datasets.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsAn Organization portal, Antibody supplier, Service resource,
View all literature mentions:OsiriX is an image processing software dedicated to DICOM images (.dcm / .DCM extension) produced by medical equipment (MRI, CT, PET, PET-CT, ...) and confocal microscopy (LSM and BioRAD-PIC format). It can also read many other file formats: TIFF (8,16, 32 bits), JPEG, PDF, AVI, MPEG and Quicktime. It is fully compliant with the DICOM standard for image comunication and image file formats. OsiriX is able to receive images transferred by DICOM communication protocol from any PACS or medical imaging modality (STORE SCP - Service Class Provider, STORE SCU - Service Class User, and Query/Retrieve) . OsiriX has been specifically designed for navigation and visualization of multimodality and multidimensional images: 2D Viewer, 3D Viewer, 4D Viewer (3D series with temporal dimension, for example: Cardiac-CT) and 5D Viewer (3D series with temporal and functional dimensions, for example: Cardiac-PET-CT). The 3D Viewer offers all modern rendering modes: Multiplanar reconstruction (MPR), Surface Rendering, Volume Rendering and Maximum Intensity Projection (MIP). All these modes support 4D data and are able to produce image fusion between two different series (for example: PET-CT). Osirix is at the same time a DICOM PACS workstation for medical imaging and an image processing software for medical research (radiology and nuclear imaging), functional imaging, 3D imaging, confocal microscopy and molecular imaging. :
View all literature mentionsSoftware performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
View all literature mentionsThis monoclonal targets CD34
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD3 antibody [SP7]
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis polyclonal targets CD19 antibody
View all literature mentionsThis polyclonal targets Immunoprecipitation & Western Blotting
View all literature mentionsThis unknown targets Rabbit IgG
View all literature mentionsThis monoclonal targets Human Retinoic Acid Receptor alpha
View all literature mentionsThis polyclonal targets POLR2AphosphoS2
View all literature mentionsThis polyclonal targets RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody - ChIP Grade
View all literature mentionsThis monoclonal targets Histone H3 (tri methyl K27) antibody [mAbcam 6002] - ChIP Grade
View all literature mentionsThis polyclonal targets Histone H3 (tri methyl K4)
View all literature mentionsThis isotype control targets Not Applicable
View all literature mentionsThis isotype control targets Not Applicable
View all literature mentionsThis isotype control targets Not Applicable
View all literature mentionsThis unknown targets Mouse
View all literature mentionsThis unknown targets Mouse IgG1 kappa Isotype Control Allophycocyanin Clone MOPC-21
View all literature mentionsThis monoclonal targets Mouse IgG2b, kappa Isotype Control
View all literature mentionsThis monoclonal targets CD16
View all literature mentionsThis monoclonal targets CD14
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD56
View all literature mentionsThis polyclonal targets RGS20 (RSG, Regulator of G-Protein Signalling 20)
View all literature mentionsThis monoclonal targets IL-17A
View all literature mentionsThis monoclonal targets IL-4
View all literature mentionsThis monoclonal targets IL-2
View all literature mentionsThis monoclonal targets IFN gamma
View all literature mentionsThis monoclonal targets Granzyme B
View all literature mentionsThis monoclonal targets Human Perforin
View all literature mentionsThis monoclonal targets Perforin
View all literature mentionsThis monoclonal targets CD8
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD1d
View all literature mentionsThis monoclonal targets HIF1 alpha
View all literature mentionsThis monoclonal targets Invariant NK T
View all literature mentionsThis unknown targets TCR Valpha24
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD34
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsCell line U266B1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line NCI-H929 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line KMS-12-BM is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line ARH-77 is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line K-562 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis monoclonal targets CD3 antibody [SP7]
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis polyclonal targets CD19 antibody
View all literature mentionsThis polyclonal targets Immunoprecipitation & Western Blotting
View all literature mentionsThis unknown targets Rabbit IgG
View all literature mentionsThis monoclonal targets Human Retinoic Acid Receptor alpha
View all literature mentionsThis polyclonal targets POLR2AphosphoS2
View all literature mentionsThis polyclonal targets RNA polymerase II CTD repeat YSPTSPS (phospho S5) antibody - ChIP Grade
View all literature mentionsThis monoclonal targets Histone H3 (tri methyl K27) antibody [mAbcam 6002] - ChIP Grade
View all literature mentionsThis polyclonal targets Histone H3 (tri methyl K4)
View all literature mentionsThis isotype control targets Not Applicable
View all literature mentionsThis isotype control targets Not Applicable
View all literature mentionsThis isotype control targets Not Applicable
View all literature mentionsThis unknown targets Mouse
View all literature mentionsThis unknown targets Mouse IgG1 kappa Isotype Control Allophycocyanin Clone MOPC-21
View all literature mentionsThis monoclonal targets Mouse IgG2b, kappa Isotype Control
View all literature mentionsThis monoclonal targets CD16
View all literature mentionsThis monoclonal targets CD14
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD56
View all literature mentionsThis polyclonal targets RGS20 (RSG, Regulator of G-Protein Signalling 20)
View all literature mentionsThis monoclonal targets IL-17A
View all literature mentionsThis monoclonal targets IL-4
View all literature mentionsThis monoclonal targets IL-2
View all literature mentionsThis monoclonal targets IFN gamma
View all literature mentionsThis monoclonal targets Granzyme B
View all literature mentionsThis monoclonal targets Human Perforin
View all literature mentionsThis monoclonal targets Perforin
View all literature mentionsThis monoclonal targets CD8
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD5
View all literature mentionsThis monoclonal targets CD1d
View all literature mentionsThis monoclonal targets HIF1 alpha
View all literature mentionsThis monoclonal targets Invariant NK T
View all literature mentionsThis unknown targets TCR Valpha24
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD34
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets CD34
View all literature mentionsThis monoclonal targets CD34
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