Bcl-2 family proteins reorganize mitochondrial membranes during apoptosis, to form pores and rearrange cristae. In vitro and in vivo analysis integrated with human genetics reveals a novel homeostatic mitochondrial function for Bcl-2 family protein Bid. Loss of full-length Bid results in apoptosis-independent, irregular cristae with decreased respiration. Bid-/- mice display stress-induced myocardial dysfunction and damage. A gene-based approach applied to a biobank, validated in two independent GWAS studies, reveals that decreased genetically determined BID expression associates with myocardial infarction (MI) susceptibility. Patients in the bottom 5% of the expression distribution exhibit >4 fold increased MI risk. Carrier status with nonsynonymous variation in Bid's membrane binding domain, BidM148T, associates with MI predisposition. Furthermore, Bid but not BidM148T associates with Mcl-1Matrix, previously implicated in cristae stability; decreased MCL-1 expression associates with MI. Our results identify a role for Bid in homeostatic mitochondrial cristae reorganization, that we link to human cardiac disease.
Pubmed ID: 30281024 RIS Download
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Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsSlide image modification software that allows the user to adjust the magnification, compare slides, pan and zoom, annotate specific areas, and perform image analysis of digital slides. Users can create macros and algorithms to automate analysis and create plots, respectively.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 1,2023. Visualize and validate complex MS/MS proteomics experiments
View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis polyclonal targets VDAC1
View all literature mentionsThis polyclonal targets donkey anti-goat IgG-HRP
View all literature mentionsThis polyclonal targets Mn SOD pAb
View all literature mentionsThis monoclonal targets slightly modified β-cytoplasmic actin N-terminal peptide, Ac-Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys, conjugated to KLH
View all literature mentionsThis unknown targets HA
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets PUMA / bbc3, N Terminus
View all literature mentionsThis monoclonal targets Pyruvate dehydrogenase E2/E3bp antibody [13G2AE2BH5 ]
View all literature mentionsThis unknown targets Mouse Mcl-1
View all literature mentionsThis polyclonal targets GAPDH
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis monoclonal targets Bim (H-5)
View all literature mentionsThis monoclonal targets Calreticulin
View all literature mentionsThis monoclonal targets OPA1
View all literature mentionsThis polyclonal targets BID
View all literature mentionsSoftware tool to detect known and novel genes associated with disease traits and provide insights into the mechanism of these associations. Used to test the molecular mechanisms through which genetic variation affects phenotype.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsSoftware tool to detect known and novel genes associated with disease traits and provide insights into the mechanism of these associations. Used to test the molecular mechanisms through which genetic variation affects phenotype.
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets Pyruvate dehydrogenase E2/E3bp antibody [13G2AE2BH5 ]
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis polyclonal targets donkey anti-goat IgG-HRP
View all literature mentionsThis polyclonal targets donkey anti-goat IgG-HRP
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets Calreticulin
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis unknown targets Mouse Mcl-1
View all literature mentionsThis monoclonal targets Pyruvate dehydrogenase E2/E3bp antibody [13G2AE2BH5 ]
View all literature mentionsThis polyclonal targets Mn SOD pAb
View all literature mentionsThis monoclonal targets OPA1
View all literature mentionsThis polyclonal targets VDAC1
View all literature mentionsThis polyclonal targets GAPDH
View all literature mentionsThis unknown targets HA
View all literature mentionsThis monoclonal targets slightly modified β-cytoplasmic actin N-terminal peptide, Ac-Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys, conjugated to KLH
View all literature mentionsThis unknown targets PUMA / bbc3, N Terminus
View all literature mentionsThis monoclonal targets Bim (H-5)
View all literature mentionsThis monoclonal targets Calreticulin
View all literature mentionsThis monoclonal targets OPA1
View all literature mentionsThis unknown targets Mouse Mcl-1
View all literature mentionsThis polyclonal targets Mn SOD pAb
View all literature mentionsThis polyclonal targets GAPDH
View all literature mentionsThis monoclonal targets slightly modified β-cytoplasmic actin N-terminal peptide, Ac-Asp-Asp-Asp-Ile-Ala-Ala-Leu-Val-Ile-Asp-Asn-Gly-Ser-Gly-Lys, conjugated to KLH
View all literature mentionsThis polyclonal targets VDAC1
View all literature mentionsThis unknown targets HA
View all literature mentionsThis unknown targets PUMA / bbc3, N Terminus
View all literature mentionsThis monoclonal targets Bim (H-5)
View all literature mentions