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PI3Kγ promotes vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis via a SOX9-dependent mechanism.

EBioMedicine | 2018

Transplant arteriosclerosis (TA) remains the major cause of chronic graft failure in solid organ transplantation. The phenotypic modulation of vascular smooth muscle cells (VSMCs) is a key event for the initiation and progression of neointimal formation and TA. This study aims to explore the role and underlying mechanism of phosphoinositide 3-kinases γ (PI3Kγ) in VSMC phenotypic modulation and TA.

Pubmed ID: 30241919 RIS Download

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

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Cell Signaling Technology (tool)

RRID:SCR_004431

Privately held company that develops and produces antibodies, ELISA kits, ChIP kits, proteomic kits, and other related reagents used to study cell signaling pathways that impact human health.

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BioVision (tool)

RRID:SCR_005057

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Image Pro Plus (tool)

RRID:SCR_007369

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 18,2023. Software package to capture, process, measure, analyze and share images and data.

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LEW (tool)

RRID:RGD_60999

Rattus norvegicus with name LEW from RGD.

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Anti-TAGLN/Transgelin antibody (antibody)

RRID:AB_443021

This polyclonal targets TAGLN/Transgelin

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SRF (D71A9) XP Rabbit mAb (antibody)

RRID:AB_10694554

This monoclonal targets SRF (D71A9) XP Rabbit mAb

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Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb (antibody)

RRID:AB_2315049

This monoclonal targets Phospho-Akt (Ser473)

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PI3 Kinase p110 (D55D5) Rabbit mAb (antibody)

RRID:AB_1904087

This monoclonal targets PI3 Kinase p110

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Myocardin (N-16) (antibody)

RRID:AB_2251111

This polyclonal targets Myocardin

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Anti-SOX9 antibody (antibody)

RRID:AB_2715497

This monoclonal targets SOX9

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HEK293T (cell line)

RRID:CVCL_0063

Cell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)

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HEK293T (cell line)

RRID:CVCL_0063

Cell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)

View all literature mentions

HEK293T (cell line)

RRID:CVCL_0063

Cell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)

View all literature mentions

Anti-TAGLN/Transgelin antibody (antibody)

RRID:AB_443021

This polyclonal targets TAGLN/Transgelin

View all literature mentions

HEK293T (cell line)

RRID:CVCL_0063

Cell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)

View all literature mentions

SRF (D71A9) XP Rabbit mAb (antibody)

RRID:AB_10694554

This monoclonal targets SRF (D71A9) XP Rabbit mAb

View all literature mentions

HEK293T (cell line)

RRID:CVCL_0063

Cell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)

View all literature mentions

Myocardin (N-16) (antibody)

RRID:AB_2251111

This polyclonal targets Myocardin

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Anti-SOX9 antibody (antibody)

RRID:AB_2715497

This monoclonal targets SOX9

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Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb (antibody)

RRID:AB_2315049

This monoclonal targets Phospho-Akt (Ser473)

View all literature mentions

PI3 Kinase p110 (D55D5) Rabbit mAb (antibody)

RRID:AB_1904087

This monoclonal targets PI3 Kinase p110

View all literature mentions