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The metabolic state of a cell is influenced by cell-extrinsic factors, including nutrient availability and growth factor signaling. Here, we present extracellular matrix (ECM) remodeling as another fundamental node of cell-extrinsic metabolic regulation. Unbiased analysis of glycolytic drivers identified the hyaluronan-mediated motility receptor as being among the most highly correlated with glycolysis in cancer. Confirming a mechanistic link between the ECM component hyaluronan and metabolism, treatment of cells and xenografts with hyaluronidase triggers a robust increase in glycolysis. This is largely achieved through rapid receptor tyrosine kinase-mediated induction of the mRNA decay factor ZFP36, which targets TXNIP transcripts for degradation. Because TXNIP promotes internalization of the glucose transporter GLUT1, its acute decline enriches GLUT1 at the plasma membrane. Functionally, induction of glycolysis by hyaluronidase is required for concomitant acceleration of cell migration. This interconnection between ECM remodeling and metabolism is exhibited in dynamic tissue states, including tumorigenesis and embryogenesis.
Pubmed ID: 30197082 RIS Download
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Database of human and mouse primer pairs for gene expression analysis by polymerase chain reaction (PCR) and quantitative PCR (qPCR). A total of 306,800 primers covering most known human and mouse genes can be accessed from the PrimerBank database, together with information on these primers such as T(m), location on the transcript and amplicon size. For each gene, at least one primer pair has been designed and in many cases alternative primer pairs exist. Primers have been designed to work under the same PCR conditions, thus facilitating high-throughput QPCR. All primers in PrimerBank were carefully designed to ensure gene specificity. All experimental validation data for mouse primers are available from PrimerBank. You can submit your primers. They will be added to the database once they are properly QCd.
View all literature mentionsThis monoclonal targets Glucose Transporter GLUT1 antibody [EPR3915]
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View all literature mentionsThis monoclonal targets Hexokinase II
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis unknown targets Biotin
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets ZFP36
View all literature mentionsThis monoclonal targets TXNIP
View all literature mentionsThis polyclonal targets Na,K-ATPase alpha 1
View all literature mentionsThis polyclonal targets Monocarboxylic acid transporter 1 antibody
View all literature mentionsThis monoclonal targets LDHA
View all literature mentionsThis recombinant monoclonal targets Ki67
View all literature mentionsThis polyclonal targets phospho-ITCH (pT222)
View all literature mentionsThis monoclonal targets CD168 antibody [EPR4055]
View all literature mentionsThis polyclonal targets Glucose Transporter GLUT3 antibody
View all literature mentionsThis monoclonal targets Glucose Transporter GLUT3
View all literature mentionsThis monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)
View all literature mentionsThis monoclonal targets p44/42 MAPK (Erk1/2)
View all literature mentionsThis polyclonal targets Elk1
View all literature mentionsThis monoclonal targets Phospho-EGF Receptor (Tyr1068)
View all literature mentionsThis monoclonal targets EGF Receptor
View all literature mentionsThis polyclonal targets Enolase-1
View all literature mentionsThis polyclonal targets Collagen IV
View all literature mentionsThis monoclonal targets Phospho-c-Jun (Ser63) (54B3) Rabbit mAb
View all literature mentionsThis polyclonal targets ALDOB
View all literature mentionsThis monoclonal targets beta-Actin
View all literature mentionsThis polyclonal targets Phospho-Acetyl-CoA Carboxylase (Ser79)
View all literature mentionsCell line TXNIP-null MEF is a Spontaneously immortalized cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsSoftware package for interpreting gene expression data. Used for interpretation of a large-scale experiment by identifying pathways and processes.
View all literature mentionsSoftware that estimates expression at transcript-level resolution and controls for variability evident across replicate libraries.
View all literature mentionsSoftware tool for transcriptome assembly and differential expression analysis for RNA-Seq. Includes script called cuffmerge that can be used to merge together several Cufflinks assemblies. It also handles running Cuffcompare as well as automatically filtering a number of transfrags that are likely to be artifacts. If the researcher has a reference GTF file, the researcher can provide it to the script to more effectively merge novel isoforms and maximize overall assembly quality.
View all literature mentionsSoftware tool for fast and high throughput alignment of shotgun cDNA sequencing reads generated by transcriptomics technologies. Fast splice junction mapper for RNA-Seq reads. Aligns RNA-Seq reads to mammalian-sized genomes using ultra high-throughput short read aligner Bowtie, and then analyzes mapping results to identify splice junctions between exons.TopHat2 is accurate alignment of transcriptomes in presence of insertions, deletions and gene fusions.
View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsSoftware tool for viewing, analyzing, and registering volumetric medical imaging data sets. It has been written on top of GTK+ and runs on any system that supports this toolkit (Linux, Windows, Mac OS X, etc.). The program incorporates automatic non-orthogonal data reslicing, allowing multiple data set to be fused without imposed constraints on the dimensions, anisotrophy, or voxel sizes of the data. Additional features include 3D ROI (ellipses, cylinders, boxes, and isocontours), multi-slice viewing, volume rendering, and data importing through the (X)MedCon library.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name B6.129-Krastm4Tyj/Nci from IMSR.
View all literature mentionsMus musculus with name B6;SJL-Tg(Krt1-15-cre/PGR*)22Cot/J from IMSR.
View all literature mentions
Mus musculus with name C.B-Igh-1b/GbmsTac-Prkdcscid-Lyst
Cell line U-87MG ATCC is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line SUM159PT is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line SUM149PT is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line SNL 76/7 is a Transformed cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line PANC-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line NCI-H661 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line NCI-H520 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line NCI-H460 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line NCI-H441 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line NCI-H358 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line NCI-H1792 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line NCI-H157 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line NCI-H1437 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line MIA PaCa-2 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line MDA-MB-453 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line MDA-MB-231 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line MDA-686 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line MCF-12A is a Spontaneously immortalized cell line with a species of origin Homo sapiens
View all literature mentionsCell line MCF-10A is a Spontaneously immortalized cell line with a species of origin Homo sapiens
View all literature mentionsCell line LPS3 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line LS030609 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line LiSa-2 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line Hs 578T is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HPSC-TAg-TERT is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HFF-1 is a Finite cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HeLa is a Cancer cell line with a species of origin Homo sapiens
View all literature mentionsCell line HCT 116 TP53(-/-) is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HCT 116 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line A-549 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line A-431 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line 3T3-L1 is a Spontaneously immortalized cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line TXNIP-null MEF is a Spontaneously immortalized cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsThis monoclonal targets Glucose Transporter GLUT1 antibody [EPR3915]
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