Personalized cancer therapy targeting somatic mutations in patient tumors is increasingly being incorporated into practice. Other therapeutic vulnerabilities resulting from changes in gene expression due to tumor specific epigenetic perturbations are progressively being recognized. These genomic and epigenomic changes are ultimately manifest in the tumor proteome and phosphoproteome. We integrated transcriptomic, epigenomic, and proteomic/phosphoproteomic data to elucidate the cellular origins and therapeutic vulnerabilities of rhabdomyosarcoma (RMS). We discovered that alveolar RMS occurs further along the developmental program than embryonal RMS. We also identified deregulation of the RAS/MEK/ERK/CDK4/6, G2/M, and unfolded protein response pathways through our integrated analysis. Comprehensive preclinical testing revealed that targeting the WEE1 kinase in the G2/M pathway is the most effective approach in vivo for high-risk RMS.
Pubmed ID: 30146332 RIS Download
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This unknown targets IgG
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View all literature mentionsThis monoclonal targets Cyclin D1
View all literature mentionsThis monoclonal targets Raised against peptide corresponding to an AA sequence at the C-terminus of mouse origin
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View all literature mentionsThis monoclonal targets cdc25C (5H9) Rabbit mAb
View all literature mentionsThis polyclonal targets Phospho-S6 Ribosomal Protein (Ser235/236)
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View all literature mentionsThis polyclonal targets H3K9me3
View all literature mentionsThis polyclonal targets H3K9me3 (HumanMouse) (Host:Rabbit)
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View all literature mentionsThis unknown targets H3K9acK14ac
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View all literature mentionsThis polyclonal targets H3K27ac
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View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 18,2023. Short reads mapping software for bisulfite sequencing reads.
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View all literature mentionsA high-performance visualization tool for interactive exploration of large, integrated genomic datasets.
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View all literature mentionsJava toolset for working with next generation sequencing data in the BAM format.
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Mus musculus with name NOD.Cg-Prkdcscid Il2rg
Cell line SaOS-2 is a Cancer cell line with a species of origin Homo sapiens (Human)
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View all literature mentionsCell line RD is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsSoftware environment and programming language for statistical computing and graphics. R is integrated suite of software facilities for data manipulation, calculation and graphical display. Can be extended via packages. Some packages are supplied with the R distribution and more are available through CRAN family.It compiles and runs on wide variety of UNIX platforms, Windows and MacOS.
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