Searching across hundreds of databases
Motor cortex (M1) lesions result in motor impairments, yet how M1 contributes to the control of movement remains controversial. To investigate the role of M1 in sensory guided motor coordination, we trained mice to navigate a virtual corridor using a spherical treadmill. This task required directional adjustments through spontaneous turning, while unexpected visual offset perturbations prompted induced turning. We found that M1 is essential for execution and learning of this visually guided task. Turn-selective layer 2/3 and layer 5 pyramidal tract (PT) neuron activation was shaped differentially with learning but scaled linearly with turn acceleration during spontaneous turns. During induced turns, however, layer 2/3 neurons were activated independent of behavioral response, while PT neurons still encoded behavioral response magnitude. Our results are consistent with a role of M1 in the detection of sensory perturbations that result in deviations from intended motor state and the initiation of an appropriate corrective response.
Pubmed ID: 30146302 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Mus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis unknown targets GFP
View all literature mentionsThis polyclonal targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgY (IgG) (H+L)
View all literature mentionsResearch areas: Cell Biology, Developmental Biology, Neurobiology, Research Tools; Mutation type: Transgene This is a legacy resource.
View all literature mentionsMus musculus with name STOCK Tg(Tlx3-cre)PL58Gsat/Mmucd from MMRRC.
View all literature mentionsMus musculus with name STOCK Slc32a1tm2(cre)Lowl/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Tg(Slc32a1-COP4*H134R/EYFP)8Gfng/J from IMSR.
View all literature mentionsMulti paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsA development environment for engineers and scientists to visualize, create, and code engineering systems. The system design software is integrated with all measurement hardware and contains signal processing IP. Other features include multithreaded execution, software deployment to hardware, and program integration into a single environment.
View all literature mentionsMulti paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsA development environment for engineers and scientists to visualize, create, and code engineering systems. The system design software is integrated with all measurement hardware and contains signal processing IP. Other features include multithreaded execution, software deployment to hardware, and program integration into a single environment.
View all literature mentionsThis polyclonal targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgY (IgG) (H+L)
View all literature mentionsMus musculus with name STOCK Tg(Tlx3-cre)PL58Gsat/Mmucd from MMRRC.
View all literature mentionsMus musculus with name STOCK Slc32a1tm2(cre)Lowl/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsThis unknown targets GFP
View all literature mentionsMus musculus with name B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name STOCK Slc32a1tm2(cre)Lowl/J from IMSR.
View all literature mentionsResearch areas: Cell Biology, Developmental Biology, Neurobiology, Research Tools; Mutation type: Transgene This is a legacy resource.
View all literature mentionsMus musculus with name STOCK Tg(Tlx3-cre)PL58Gsat/Mmucd from MMRRC.
View all literature mentionsThis unknown targets GFP
View all literature mentionsMus musculus with name B6.Cg-Tg(Slc32a1-COP4*H134R/EYFP)8Gfng/J from IMSR.
View all literature mentionsMus musculus with name B6.Cg-Tg(Slc32a1-COP4*H134R/EYFP)8Gfng/J from IMSR.
View all literature mentionsResearch areas: Cell Biology, Developmental Biology, Neurobiology, Research Tools; Mutation type: Transgene This is a legacy resource.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
