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Alternative oxidases (AOXs) bypass respiratory complexes III and IV by transferring electrons from coenzyme Q directly to O2. They have therefore been proposed as a potential therapeutic tool for mitochondrial diseases. We crossed the severely myopathic skeletal muscle-specific COX15 knockout (KO) mouse with an AOX-transgenic mouse. Surprisingly, the double KO-AOX mutants had decreased lifespan and a substantial worsening of the myopathy compared with KO alone. Decreased ROS production in KO-AOX versus KO mice led to impaired AMPK/PGC-1α signaling and PAX7/MYOD-dependent muscle regeneration, blunting compensatory responses. Importantly, the antioxidant N-acetylcysteine had a similar effect, decreasing the lifespan of KO mice. Our findings have major implications for understanding pathogenic mechanisms in mitochondrial diseases and for the design of therapies, highlighting the benefits of ROS signaling and the potential hazards of antioxidant treatment.
Pubmed ID: 30122554 RIS Download
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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 2nd, 2023. Sequence composition based classifier for metagenomic sequences. It works by capturing signatures of each sequence based on the sequence composition. Each sequence is modeled as a walk in a de Bruijn graph with underlying Markov chain properties. ClaMS captures stationary parameters of the underlying Markov chain as well as structural parameters of the underlying de Bruijn graph to form this signature. In practice, for each sequence to binned, such a signature is computed and matched to similar signatures computed for the training sets. The best match that also qualifies the normalized distance cut-off wins. In the case that the best match does not qualify this cut-off, the sequence remains un-binned.
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsThis polyclonal targets TFAM antibody
View all literature mentionsThis polyclonal targets PYCR1
View all literature mentionsThis monoclonal targets eIF2alpha (Ser51)
View all literature mentionsThis polyclonal targets Phospho-AMPKα (Thr172)
View all literature mentionsThis monoclonal targets 4E-BP1, phospho (Thr37 / Thr46)
View all literature mentionsThis polyclonal targets PPARGC1A
View all literature mentionsThis unknown targets PAX7
View all literature mentionsThis monoclonal targets Human SQSTM1
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View all literature mentionsThis polyclonal targets MTHFD2
View all literature mentionsThis monoclonal targets SOD2 antibody [2A1]
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIB
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIA
View all literature mentionsThis monoclonal targets Myosin heavy chain (slow, alpha- and beta-)
View all literature mentionsThis polyclonal targets Hsp60
View all literature mentionsThis monoclonal targets HSC 70 (B-6)
View all literature mentionsThis polyclonal targets Grp75
View all literature mentionsThis monoclonal targets GAPDH antibody [6C5]
View all literature mentionsThis polyclonal targets eIF2 alpha
View all literature mentionsThis polyclonal targets AMPK-alpha
View all literature mentionsThis polyclonal targets 4E-BP1
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsThis monoclonal targets 4E-BP1, phospho (Thr37 / Thr46)
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsThis monoclonal targets eIF2alpha (Ser51)
View all literature mentionsThis polyclonal targets TFAM antibody
View all literature mentionsThis polyclonal targets Phospho-AMPKα (Thr172)
View all literature mentionsThis polyclonal targets PYCR1
View all literature mentionsThis polyclonal targets PPARGC1A
View all literature mentionsThis monoclonal targets NRF2
View all literature mentionsThis monoclonal targets MyoD
View all literature mentionsThis polyclonal targets MTHFD2
View all literature mentionsThis unknown targets PAX7
View all literature mentionsThis monoclonal targets SOD2 antibody [2A1]
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIB
View all literature mentionsThis monoclonal targets Human SQSTM1
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIA
View all literature mentionsThis monoclonal targets Myosin heavy chain (slow, alpha- and beta-)
View all literature mentionsThis polyclonal targets Hsp60
View all literature mentionsThis monoclonal targets HSC 70 (B-6)
View all literature mentionsThis polyclonal targets Grp75
View all literature mentionsThis monoclonal targets GAPDH antibody [6C5]
View all literature mentionsThis polyclonal targets eIF2 alpha
View all literature mentionsThis polyclonal targets AMPK-alpha
View all literature mentionsThis polyclonal targets 4E-BP1
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
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