Searching across hundreds of databases
Long-term depression (LTD) of AMPA-type glutamate receptor (AMPA receptor)-mediated synaptic transmission has been proposed as a cellular substrate for learning and memory. Although activity-induced AMPA receptor endocytosis is believed to underlie LTD, it remains largely unclear whether LTD and AMPA receptor endocytosis at specific synapses are causally linked to learning and memory in vivo. Here we developed a new optogenetic tool, termed PhotonSABER, which enabled the temporal, spatial, and cell-type-specific control of AMPA receptor endocytosis at active synapses, while the basal synaptic properties and other forms of synaptic plasticity were unaffected. We found that fiberoptic illumination to Purkinje cells expressing PhotonSABER in vivo inhibited cerebellar motor learning during adaptation of the horizontal optokinetic response and vestibulo-ocular reflex, as well as synaptic AMPA receptor decrease in the flocculus. Our results demonstrate that LTD and AMPA receptor endocytosis at specific neuronal circuits were directly responsible for motor learning in vivo. VIDEO ABSTRACT.
Pubmed ID: 30122381 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This polyclonal targets Calbindin-D-28K (EG-20) antibody produced in rabbit
View all literature mentionsThis polyclonal secondary targets IgG
View all literature mentionsThis polyclonal secondary targets IgG
View all literature mentionsThis polyclonal secondary targets IgG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets MAP2A, 2B
View all literature mentionsThis monoclonal targets Actin antibody produced in mouse
View all literature mentionsThis unknown targets LAMP1
View all literature mentionsThis monoclonal targets CD71
View all literature mentionsThis monoclonal targets Mannose 6 Phosphate Receptor
View all literature mentionsThis polyclonal targets Calbindin 28kD
View all literature mentionsThis polyclonal targets FLAG
View all literature mentionsThis polyclonal targets HA Tag
View all literature mentionsThis monoclonal targets HA
View all literature mentionsThis unknown targets
View all literature mentionsStatistical analysis and scientific graphing software for Windows OS.
View all literature mentionsCell line COS-7 is a Transformed cell line with a species of origin Chlorocebus aethiops (Green monkey)
View all literature mentionsVector graphics software to create digital graphics, illustrations, and typography for several types of media: print, web, interactive, video, and mobile.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsMulti paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.
View all literature mentionsSoftware package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsImage processing software package that provides scientific image acquisition, visualization, analysis and laboratory automation in single package. Allows users to acquire grayscale and color images from most video cameras, variety of cooled CCD digital cameras and high resolution flatbed scanners. Capable of analyzing image data in seven different data types, this program can calculate integrated intensity, mean, min, and max values plus several morphometric parameters on object regions within images.
View all literature mentionsThis polyclonal targets Calbindin-D-28K (EG-20) antibody produced in rabbit
View all literature mentionsStatistical analysis and scientific graphing software for Windows OS.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
