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Targeting the Tie2-αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis.

BMC biology | 2018

Increased activity of the receptor tyrosine kinase Tie2 has been implicated in the promotion of pathological angiogenesis. This activity is mainly mediated through angiopoietin (Ang)1- and Ang2-dependent activation of integrins by Tie2, rendering the Ang/Tie2/integrin axis an attractive putative target for cancer therapeutics.

Pubmed ID: 30119679 RIS Download

Research resources used in this publication

Associated grants

None

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.


GE Healthcare (tool)

RRID:SCR_000004

A commercial antibody supplier and provider of various services.

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GraphPad Prism (tool)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

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Thermo Fisher Scientific (tool)

RRID:SCR_008452

Commercial vendor and service provider of laboratory reagents and antibodies. Supplier of scientific instrumentation, reagents and consumables, and software services.

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BD Biosciences (tool)

RRID:SCR_013311

An Antibody supplier

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ATCC (tool)

RRID:SCR_001672

Global nonprofit biological resource center (BRC) and research organization that provides biological products, technical services and educational programs to private industry, government and academic organizations. Its mission is to acquire, authenticate, preserve, develop and distribute biological materials, information, technology, intellectual property and standards for the advancement and application of scientific knowledge. The primary purpose of ATCC is to use its resources and experience as a BRC to become the world leader in standard biological reference materials management, intellectual property resource management and translational research as applied to biomaterial development, standardization and certification. ATCC characterizes cell lines, bacteria, viruses, fungi and protozoa, as well as develops and evaluates assays and techniques for validating research resources and preserving and distributing biological materials to the public and private sector research communities.

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GenScript (tool)

RRID:SCR_002891

Commercial organization which provides life science services and products to researchers. They specialize in gene synthesis, peptide, protein, antibody and preclinical drug development service.

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FlowJo (tool)

RRID:SCR_008520

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

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GROMACS (tool)

RRID:SCR_014565

A software package created to perform molecular dynamics. It is primarily designed for biochemical molecules like proteins, lipids and nucleic acids that have many complicated bonded interactions, but it can also be used for research on non-biological systems, such as polymers.

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FITC anti-human CD51 (antibody)

RRID:AB_940558

This monoclonal targets CD51

View all literature mentions

Myc Tag Polyclonal Antibody (antibody)

RRID:AB_2535826

This unknown targets Myc Tag

View all literature mentions

β-Actin (13E5) Rabbit mAb (antibody)

RRID:AB_2223172

This monoclonal targets beta-Actin

View all literature mentions

Anti-rabbit IgG, HRP-linked Antibody (antibody)

RRID:AB_2099233

This polyclonal secondary targets IgG

View all literature mentions

FAK Antibody (antibody)

RRID:AB_2269034

This polyclonal targets Ptk2

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Phospho-FAK (Tyr397) (D20B1) Rabbit mAb (antibody)

RRID:AB_10891442

This monoclonal targets Phospho-FAK (Tyr397) (D20B1) Rabbit mAb

View all literature mentions

Akt (pan) (C67E7) Rabbit mAb (antibody)

RRID:AB_915783

This monoclonal targets Akt (pan) (C67E7) Rabbit mAb

View all literature mentions

Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb (antibody)

RRID:AB_2315049

This monoclonal targets Phospho-Akt (Ser473)

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Tie2 (D9D10) Rabbit mAb (antibody)

RRID:AB_10949315

This monoclonal targets Tie2 (D9D10) Rabbit mAb

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PE anti-DYKDDDDK Tag (antibody)

RRID:AB_2563147

This monoclonal targets DYKDDDDK

View all literature mentions

APC anti-DYKDDDDK Tag (antibody)

RRID:AB_2561497

This monoclonal targets DYKDDDDK

View all literature mentions

APC anti-human CD41 (antibody)

RRID:AB_2129464

This monoclonal targets CD41

View all literature mentions

APC anti-human CD49c (integrin alpha3) (antibody)

RRID:AB_10641703

This monoclonal targets APC anti-human CD49c (integrin alpha3)

View all literature mentions

APC anti-human CD49d (antibody)

RRID:AB_314433

This monoclonal targets CD49d

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FITC anti-human CD49a (antibody)

RRID:AB_2129084

This monoclonal targets CD49a

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TIME (cell line)

RRID:CVCL_0047

Cell line TIME is a Telomerase immortalized cell line with a species of origin Homo sapiens (Human)

View all literature mentions

β-Actin (13E5) Rabbit mAb (antibody)

RRID:AB_2223172

This monoclonal targets beta-Actin

View all literature mentions

Anti-rabbit IgG, HRP-linked Antibody (antibody)

RRID:AB_2099233

This polyclonal secondary targets IgG

View all literature mentions

Phospho-FAK (Tyr397) (D20B1) Rabbit mAb (antibody)

RRID:AB_10891442

This monoclonal targets Phospho-FAK (Tyr397) (D20B1) Rabbit mAb

View all literature mentions

Akt (pan) (C67E7) Rabbit mAb (antibody)

RRID:AB_915783

This monoclonal targets Akt (pan) (C67E7) Rabbit mAb

View all literature mentions

Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb (antibody)

RRID:AB_2315049

This monoclonal targets Phospho-Akt (Ser473)

View all literature mentions

Tie2 (D9D10) Rabbit mAb (antibody)

RRID:AB_10949315

This monoclonal targets Tie2 (D9D10) Rabbit mAb

View all literature mentions

PE anti-DYKDDDDK Tag (antibody)

RRID:AB_2563147

This monoclonal targets DYKDDDDK

View all literature mentions

APC anti-DYKDDDDK Tag (antibody)

RRID:AB_2561497

This monoclonal targets DYKDDDDK

View all literature mentions

TIME (cell line)

RRID:CVCL_0047

Cell line TIME is a Telomerase immortalized cell line with a species of origin Homo sapiens (Human)

View all literature mentions

APC anti-human CD41 (antibody)

RRID:AB_2129464

This monoclonal targets CD41

View all literature mentions

APC anti-human CD49c (integrin alpha3) (antibody)

RRID:AB_10641703

This monoclonal targets APC anti-human CD49c (integrin alpha3)

View all literature mentions

β-Actin (13E5) Rabbit mAb (antibody)

RRID:AB_2223172

This monoclonal targets beta-Actin

View all literature mentions

Anti-rabbit IgG, HRP-linked Antibody (antibody)

RRID:AB_2099233

This polyclonal secondary targets IgG

View all literature mentions

Phospho-FAK (Tyr397) (D20B1) Rabbit mAb (antibody)

RRID:AB_10891442

This monoclonal targets Phospho-FAK (Tyr397) (D20B1) Rabbit mAb

View all literature mentions

Akt (pan) (C67E7) Rabbit mAb (antibody)

RRID:AB_915783

This monoclonal targets Akt (pan) (C67E7) Rabbit mAb

View all literature mentions

Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb (antibody)

RRID:AB_2315049

This monoclonal targets Phospho-Akt (Ser473)

View all literature mentions

Tie2 (D9D10) Rabbit mAb (antibody)

RRID:AB_10949315

This monoclonal targets Tie2 (D9D10) Rabbit mAb

View all literature mentions

PE anti-DYKDDDDK Tag (antibody)

RRID:AB_2563147

This monoclonal targets DYKDDDDK

View all literature mentions

APC anti-DYKDDDDK Tag (antibody)

RRID:AB_2561497

This monoclonal targets DYKDDDDK

View all literature mentions

TIME (cell line)

RRID:CVCL_0047

Cell line TIME is a Telomerase immortalized cell line with a species of origin Homo sapiens (Human)

View all literature mentions

APC anti-human CD41 (antibody)

RRID:AB_2129464

This monoclonal targets CD41

View all literature mentions

APC anti-human CD49c (integrin alpha3) (antibody)

RRID:AB_10641703

This monoclonal targets APC anti-human CD49c (integrin alpha3)

View all literature mentions

FITC anti-human CD51 (antibody)

RRID:AB_940558

This monoclonal targets CD51

View all literature mentions

Myc Tag Polyclonal Antibody (antibody)

RRID:AB_2535826

This unknown targets Myc Tag

View all literature mentions

FITC anti-human CD51 (antibody)

RRID:AB_940558

This monoclonal targets CD51

View all literature mentions

Myc Tag Polyclonal Antibody (antibody)

RRID:AB_2535826

This unknown targets Myc Tag

View all literature mentions