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Therapeutic antibodies targeting ovarian cancer (OvCa)-enriched receptors have largely been disappointing due to limited tumor-specific antibody-dependent cellular cytotoxicity. Here we report a symbiotic approach that is highly selective and superior compared with investigational clinical antibodies. This bispecific-anchored cytotoxicity activator antibody is rationally designed to instigate "cis" and "trans" cytotoxicity by combining specificities against folate receptor alpha-1 (FOLR1) and death receptor 5 (DR5). Whereas the in vivo agonist DR5 signaling requires FcγRIIB interaction, the FOLR1 anchor functions as a primary clustering point to retain and maintain a high level of tumor-specific apoptosis. The presented proof of concept study strategically makes use of a tumor cell-enriched anchor receptor for agonist death receptor targeting to potentially generate a clinically viable strategy for OvCa.
Pubmed ID: 30107179 RIS Download
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This monoclonal secondary targets IgG1 Fc
View all literature mentionsThis monoclonal targets Folate Binding Protein
View all literature mentionsThis polyclonal targets DR5 antibody
View all literature mentionsThis polyclonal targets IgG
View all literature mentionsThis polyclonal secondary targets IgG
View all literature mentionsThis monoclonal targets E-Cadherin
View all literature mentionsThis monoclonal targets GAPDH
View all literature mentionsThis monoclonal targets CASP3
View all literature mentionsThis polyclonal targets Cleaved Caspase-3 (Asp175)
View all literature mentionsThis polyclonal targets alpha-Tubulin
View all literature mentionsThis unknown targets Folate Receptor alpha
View all literature mentionsThis polyclonal targets TNFRSF10B
View all literature mentionsSoftware tool for flow and image cytometry data analysis by De Novo Software company.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsCell line OVCAR-3 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line SK-OV-3 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line COLO 205 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line 166-ME SK is a Finite cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line OVCAR-4 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionslaboratory mouse with name C.BKa-Prkdcscid/Icr from MGI.
View all literature mentionsMus musculus with name Crl:CD1(ICR) from IMSR.
View all literature mentionslaboratory mouse with name Hsd:Athymic Nude-Foxn1nu from MGI.
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