Juvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative disorder of early childhood characterized by expansion of clonal myelomonocytic cells and hyperactive Ras/MAPK signaling. The disorder is caused by somatic and/or germline mutations in genes involved in the Ras/MAPK and JAK/STAT signaling pathways, including CBL. Here we describe the generation of an iPSC line with a homozygous CBL c.1111T->C (Y371H) mutation, designated CHOPJMML1854.
Pubmed ID: 30096712 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Commercial organization for research and development genomics services and technical support to researchers.
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal targets Goat IgG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets Human Otx2 Affinity Purified Ab
View all literature mentionsThis polyclonal targets Human SOX17
View all literature mentionsThis polyclonal targets Human/Mouse Brachyury Affinity Purified Ab
View all literature mentionsThis polyclonal targets SOX2
View all literature mentionsThis monoclonal targets Nanog
View all literature mentionsThis monoclonal targets Oct-3/4
View all literature mentionsThis monoclonal targets TRA-1-81
View all literature mentionsThis monoclonal targets TRA-1-60-R
View all literature mentionsThis monoclonal targets SSEA-4
View all literature mentionsThis monoclonal targets SSEA-3
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal targets Goat IgG
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal targets Human Otx2 Affinity Purified Ab
View all literature mentionsThis polyclonal targets Human SOX17
View all literature mentionsThis polyclonal targets Human/Mouse Brachyury Affinity Purified Ab
View all literature mentionsThis polyclonal targets SOX2
View all literature mentionsThis monoclonal targets Nanog
View all literature mentionsThis monoclonal targets Oct-3/4
View all literature mentionsThis monoclonal targets TRA-1-81
View all literature mentionsThis monoclonal targets TRA-1-60-R
View all literature mentionsThis monoclonal targets SSEA-4
View all literature mentionsThis monoclonal targets SSEA-3
View all literature mentions