Searching across hundreds of databases
The neuromodulation of the greater occipital nerve (GON) has proved effective to treat chronic refractory neurovascular headaches, in particular migraine and cluster headache. Moreover, animal studies have shown convergence of cervical and trigeminal afferents on the same territories of the upper cervical and lower medullary dorsal horn (DH), the so-called trigeminocervical complex (TCC), and recent studies in rat models of migraine and craniofacial neuropathy have shown that GON block or stimulation alter nociceptive processing in TCC. The present study examines in detail the anatomy of GON and its central projections in the rat applying different tracers to the nerve and quantifying its ultrastructure, the ganglion neurons subserving GON, and their innervation territories in the spinal cord and brainstem. With considerable intersubject variability in size, GON contains on average 900 myelinated and 3,300 unmyelinated axons, more than 90% of which emerge from C2 ganglion neurons. Unmyelinated afferents from GON innervates exclusively laminae I-II of the lateral DH, mostly extending along segments C2-3 . Myelinated fibers distribute mainly in laminae I and III-V of the lateral DH between C1 and C6 and, with different terminal patterns, in medial parts of the DH at upper cervical segments, and ventrolateral rostral cuneate, paratrigeminal, and marginal part of the spinal caudal and interpolar nuclei. Sparse projections also appear in other locations nearby. These findings will help to better understand the bases of sensory convergence on spinomedullary systems, a critical pathophysiological factor for pain referral and spread in severe painful craniofacial disorders.
Pubmed ID: 30080243 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG, whole molecule
View all literature mentionsThis unknown targets Cholera Toxin
View all literature mentionsThis polyclonal targets Tyrosine Hydroxylase
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets Choline Acetyltransferase
View all literature mentionsMicroscope software platform which integrates Leica automated microscopes and digital cameras and provides one common user interface.
View all literature mentions
THIS RESOURCE IS NO LONGER IN SERVICE, documented on May 18, 2018; A software which provides unbiased stereological estimates of numbers, lengths, areas, and volumes present in images that were captured by microscopes or virtual slides. This software is intended to estimate structural information in a 3D format from 2D tissue sections.
There are other software tools at this company, but they have either changed names or are simply different software tools.
Software application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.
View all literature mentionsSoftware package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.
View all literature mentionsGraphic design software which can be used for vector illustration and page layout, web design, and photo editing. Features include: search, preview, application and transformation capabilities for both vector pattern and bitmap pattern fills; a fill engine with complete control over fountain, bitmap pattern and vector pattern fills; templates for website design; and vector shaping and page layout tools.
View all literature mentionsThis unknown targets Rabbit IgG, whole molecule
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis unknown targets
View all literature mentionsSoftware package used for interactive, or batched, statistical analysis in social science, health sciences and marketing. Software platform offers advanced statistical analysis, a library of machine-learning algorithms, text analysis, open-source extensibility, integration with big data and deployment into applications.Versions that were produced by SPSS Inc. before the IBM acquisition (Versions 18 and earlier) would be given origin or publisher of SPSS Inc. in Chicago.
View all literature mentionsSoftware application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.
View all literature mentions
THIS RESOURCE IS NO LONGER IN SERVICE, documented on May 18, 2018; A software which provides unbiased stereological estimates of numbers, lengths, areas, and volumes present in images that were captured by microscopes or virtual slides. This software is intended to estimate structural information in a 3D format from 2D tissue sections.
There are other software tools at this company, but they have either changed names or are simply different software tools.
Microscope software platform which integrates Leica automated microscopes and digital cameras and provides one common user interface.
View all literature mentionsGraphic design software which can be used for vector illustration and page layout, web design, and photo editing. Features include: search, preview, application and transformation capabilities for both vector pattern and bitmap pattern fills; a fill engine with complete control over fountain, bitmap pattern and vector pattern fills; templates for website design; and vector shaping and page layout tools.
View all literature mentionsThis polyclonal targets Tyrosine Hydroxylase
View all literature mentionsThis polyclonal targets Choline Acetyltransferase
View all literature mentionsThis unknown targets
View all literature mentionsThis unknown targets Cholera Toxin
View all literature mentionsThis unknown targets Rabbit IgG, whole molecule
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets
View all literature mentionsThis unknown targets IgG (H+L)
View all literature mentionsThis polyclonal targets Choline Acetyltransferase
View all literature mentionsThis polyclonal targets Tyrosine Hydroxylase
View all literature mentionsThis unknown targets Cholera Toxin
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
