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The development of medial temporal lobe circuits is critical for subsequent learning and memory functions later in life. The present study reports the expression of progesterone receptor (PR), a powerful transcription factor of the nuclear steroid receptor superfamily, in Cajal-Retzius cells of the molecular layer of the dentate gyrus of rats. PR was transiently expressed from the day of birth through postnatal day 21, but was absent thereafter. Although PR immunoreactive (PR-ir) cells did not clearly express typical markers of mature neurons, they possessed an ultrastructural morphology consistent with neurons. PRir cells did not express markers for GABAergic neurons, neuronal precursor cells, nor radial glia. However, virtually all PR cells co-expressed the calcium binding protein, calretinin, and the glycoprotein, reelin, both reliable markers for Cajal-Retzius neurons, a transient population of developmentally critical pioneer neurons that guide synaptogenesis of perforant path afferents and histogenesis of the dentate gyrus. Indeed, inhibition of PR activity during the first two weeks of life impaired adult performance on both the novel object recognition and object placement memory tasks, two behavioral tasks hypothesized to describe facets of episodic-like memory in rodents. These findings suggest that PR plays an unexplored and important role in the development of hippocampal circuitry and adult memory function.
Pubmed ID: 30069875 RIS Download
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This monoclonal targets Vimentin antibody produced in mouse
View all literature mentionsThis monoclonal targets Reelin, aa164-189 mreelin
View all literature mentionsThis monoclonal targets Nestin
View all literature mentionsThis monoclonal targets MAP-2 (Microtubule Associated Protein, MAP-2A and -2B)
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets Calretinin
View all literature mentionsPublic image processing and analysis program for Macintosh.
View all literature mentionsThis monoclonal targets Vimentin antibody produced in mouse
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets Nestin
View all literature mentionsThis monoclonal targets MAP-2 (Microtubule Associated Protein, MAP-2A and -2B)
View all literature mentionsThis monoclonal targets Reelin, aa164-189 mreelin
View all literature mentionsThis polyclonal targets Calretinin
View all literature mentionsPublic image processing and analysis program for Macintosh.
View all literature mentionsThis monoclonal targets Vimentin antibody produced in mouse
View all literature mentionsThis monoclonal targets Reelin, aa164-189 mreelin
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets Nestin
View all literature mentionsThis monoclonal targets MAP-2 (Microtubule Associated Protein, MAP-2A and -2B)
View all literature mentionsThis polyclonal targets Calretinin
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
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